Seroreactivity to human papillomavirus types 16, 18, 31, and 45 virus- like particles in a case-control study of cervical squamous intraepithelial lesions

L. Wideroff, M. Schiffman, P. Haderer, A. Armstrong, C. E. Greer, M. M. Manos, R. D. Burk, D. R. Scott, M. E. Sherman, J. T. Schiller, R. N. Hoover, R. E. Tarone, R. Kirnbauer

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Serum IgG antibodies to human papillomavirus (HPV) types 16, 18, 31, and 45 virus-like particles were measured in a nested case-control study of cervical squamous intraepithelial lesions. HPV-16 seroreactivity was strongly associated with HPV-16 DNA detection (odds ratio, 9.0; 95% confidence interval, 4.4-19.4), and similar type specificity was observed for HPV-31 and -45. In contrast, seroreactivity to any type was associated with elevated seroreactivity to all others. Among cases and controls, HPV-16 showed the highest seroprevalence, with 23.8% of 80 cases and 10.5% of 258 controls seroreactive to HPV-16 alone, and another 27.5% and 5.4%, respectively, seroreactive to HPV-16 plus other types. Overall, 24 (30.0%) cases and 17 (6.6%) controls were seroreactive to multiple types. These data suggest that seroreactivity to a given type reflects mainly type-specific HPV infection as measured by DNA detection and may also signal past exposure to other types that are now only serologically detected.

Original languageEnglish (US)
Pages (from-to)1424-1428
Number of pages5
JournalJournal of Infectious Diseases
Issue number5
Publication statusPublished - Nov 9 1999


ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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