TY - JOUR
T1 - Seroprevalence of 8 oncogenic human papillomavirus genotypes and acquired immunity against reinfection
AU - Wilson, Lauren
AU - Pawlita, Michael
AU - Castle, Phillip E.
AU - Waterboer, Tim
AU - Sahasrabuddhe, Vikrant
AU - Gravitt, Patti E.
AU - Schiffman, Mark
AU - Wentzensen, Nicolas
PY - 2014/8/1
Y1 - 2014/8/1
N2 - Background. Natural human papillomavirus (HPV) antibody titers have shown protection against subsequent HPV infection, but previous studies were restricted to few HPV genotypes.We examined the association of naturally occurring antibodies against 8 carcinogenic HPV types with subsequent infections. Methods. A total of 2302 women enrolled in the Atypical Squamous Cells of Undetermined Significance/Low-Grade Squamous Intraepithelial Lesion Triage Study provided blood samples at baseline. Serum samples were tested for antibodies against 8 carcinogenic HPV genotypes (16, 18, 31, 33, 35, 45, 52, and 58) using a multiplex serology assay.We analyzed the relationship between HPV antibodies and HPV infection during 2 years of follow-up among women negative for the specific HPV type at baseline. Results. Baseline seroprevalence for HPV16 L1 was associated with decreased risk of DNA positivity for HPV16 (odds ratio, 0.39 [95% confidence interval, .18-.86]) at ≥2 follow-up visits. We observed similar but nonsignificant decreased risks for HPV18 and 31. These findings were restricted to women reporting a new sex partner during follow-up. There was no association between baseline seroprevalence and detection of precancer during follow-up. Conclusions. Seroprevalence conferred protection against subsequent HPV infection for HPV16 and indicated possible protection for 2 other genotypes, suggesting that this effect is common to several HPV genotypes.
AB - Background. Natural human papillomavirus (HPV) antibody titers have shown protection against subsequent HPV infection, but previous studies were restricted to few HPV genotypes.We examined the association of naturally occurring antibodies against 8 carcinogenic HPV types with subsequent infections. Methods. A total of 2302 women enrolled in the Atypical Squamous Cells of Undetermined Significance/Low-Grade Squamous Intraepithelial Lesion Triage Study provided blood samples at baseline. Serum samples were tested for antibodies against 8 carcinogenic HPV genotypes (16, 18, 31, 33, 35, 45, 52, and 58) using a multiplex serology assay.We analyzed the relationship between HPV antibodies and HPV infection during 2 years of follow-up among women negative for the specific HPV type at baseline. Results. Baseline seroprevalence for HPV16 L1 was associated with decreased risk of DNA positivity for HPV16 (odds ratio, 0.39 [95% confidence interval, .18-.86]) at ≥2 follow-up visits. We observed similar but nonsignificant decreased risks for HPV18 and 31. These findings were restricted to women reporting a new sex partner during follow-up. There was no association between baseline seroprevalence and detection of precancer during follow-up. Conclusions. Seroprevalence conferred protection against subsequent HPV infection for HPV16 and indicated possible protection for 2 other genotypes, suggesting that this effect is common to several HPV genotypes.
KW - Human papillomavirus
KW - Natural immunity
KW - Serology
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U2 - 10.1093/infdis/jiu104
DO - 10.1093/infdis/jiu104
M3 - Article
C2 - 24569064
AN - SCOPUS:84898596632
SN - 0022-1899
VL - 210
SP - 448
EP - 455
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 3
ER -
