Seronegative chronic relapsing neuroborreliosis

Christine Lawrence; Richard B. Lipton; Franklin D. Lowy; P. K. Coyle

doi:10.1159/000117104

Seronegative chronic relapsing neuroborreliosis

Christine Lawrence, Richard B. Lipton, Franklin D. Lowy, P. K. Coyle

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

We report an unusual patient with evidence of Borrelia burgdorferi infection who experienced repeated neurologic relapses despite aggressive antibiotic therapy. Each course of therapy was associated with a Jarisch-Herxheimer-like reaction. Although the patient never had detectable free antibodies to B. burg-dorferi in serum or spinal fluid, the CSF was positive on multiple occasions for complexed anti-B, burgdorferi antibodies, B burgdorferi nucleic acids and free antigen.

Original language	English (US)
Pages (from-to)	113-117
Number of pages	5
Journal	European Neurology
Volume	35
Issue number	2
DOIs	https://doi.org/10.1159/000117104
State	Published - Jan 1 1995
Externally published	Yes

Keywords

Herxheimer
Immune complex
Lyme disease, Seronegative

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1159/000117104

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AU - Lipton, Richard B.

AU - Lowy, Franklin D.

AU - Coyle, P. K.

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AB - We report an unusual patient with evidence of Borrelia burgdorferi infection who experienced repeated neurologic relapses despite aggressive antibiotic therapy. Each course of therapy was associated with a Jarisch-Herxheimer-like reaction. Although the patient never had detectable free antibodies to B. burg-dorferi in serum or spinal fluid, the CSF was positive on multiple occasions for complexed anti-B, burgdorferi antibodies, B burgdorferi nucleic acids and free antigen.

KW - Herxheimer

KW - Immune complex

KW - Lyme disease, Seronegative

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Seronegative chronic relapsing neuroborreliosis

Abstract

Keywords

ASJC Scopus subject areas

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