Serologic markers of viral infection and risk of non-Hodgkin lymphoma: A pooled study of three prospective cohorts in China and Singapore

Bryan A. Bassig, Martina Willhauck-Fleckenstein, Xiao Ou Shu, Woon Puay Koh, Yu Tang Gao, Mark P. Purdue, Yong Bing Xiang, Jennifer Adams-Haduch, Renwei Wang, Nicole Brenner, Tim Waterboer, Angelika Michel, Bu Tian Ji, Howard D. Hosgood, Charles S. Rabkin, Gong Yang, Jason Y.Y. Wong, Jinming Zhang, Wei Hu, Wei Jie SeowWong Ho Chow, Michael Pawlita, Wei Zheng, Jian Min Yuan, Qing Lan, Nathaniel Rothman

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Incidence rates of non-Hodgkin lymphoma (NHL) and distributions of certain viruses differ between East Asian and Western populations. There are limited data on associations between serologic markers of multiple viral infections in pre-diagnostic blood and NHL risk in East Asians. We conducted a nested case-control study of 214 NHL cases and 214 matched controls from three population-based prospective cohorts in Shanghai and Singapore. Antibodies against antigens from herpesviruses, Hepatitis B (HBV) and C (HCV) virus and polyomaviruses were measured in plasma or serum using fluorescent bead-based multiplex assays. Conditional logistic regression was used to evaluate associations between antibody levels and NHL risk. An increased risk of NHL was observed for higher compared to lower EA-D (Odds Ratio (OR)=2.04, 95% Confidence Interval (CI)=1.10-3.81; ptrend=0.005) and ZEBRA (OR=2.17, 95% CI=0.96-4.89; ptrend=0.008) Epstein-Barr Virus (EBV) antibodies, as well as for antibody seropositivity against the IE1A human herpesvirus-6 (HHV-6) antigen (OR=1.85, 95% CI=1.04-3.29). An increased NHL risk was also observed for higher compared to lower antibodies against the HBV-HBc and HBe antigens. An increased risk of NHL in relation to EBV and HBV infection in East Asians is consistent with findings in several studies of Western populations, suggesting similar viral risk factors for NHL in these diverse populations with distinct patterns of NHL. The association between HHV-6 antibodies and NHL has not previously been reported in a prospective study in this population and will require replication.

Original languageEnglish (US)
JournalInternational Journal of Cancer
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Singapore
Virus Diseases
Non-Hodgkin's Lymphoma
China
Prospective Studies
Antibodies
Human Herpesvirus 6
Population
Odds Ratio
Confidence Intervals
Viruses
Cercopithecine Herpesvirus 1
Antigens
Polyomavirus
Epstein-Barr Virus Infections
Hepatitis C
Hepatitis B
Human Herpesvirus 4
Case-Control Studies
Logistic Models

Keywords

  • Epstein-Barr virus
  • Hepatitis
  • Multiplex serology
  • Non-Hodgkin lymphoma
  • Viral antibodies

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Bassig, B. A., Willhauck-Fleckenstein, M., Shu, X. O., Koh, W. P., Gao, Y. T., Purdue, M. P., ... Rothman, N. (Accepted/In press). Serologic markers of viral infection and risk of non-Hodgkin lymphoma: A pooled study of three prospective cohorts in China and Singapore. International Journal of Cancer. https://doi.org/10.1002/ijc.31385

Serologic markers of viral infection and risk of non-Hodgkin lymphoma : A pooled study of three prospective cohorts in China and Singapore. / Bassig, Bryan A.; Willhauck-Fleckenstein, Martina; Shu, Xiao Ou; Koh, Woon Puay; Gao, Yu Tang; Purdue, Mark P.; Xiang, Yong Bing; Adams-Haduch, Jennifer; Wang, Renwei; Brenner, Nicole; Waterboer, Tim; Michel, Angelika; Ji, Bu Tian; Hosgood, Howard D.; Rabkin, Charles S.; Yang, Gong; Wong, Jason Y.Y.; Zhang, Jinming; Hu, Wei; Seow, Wei Jie; Chow, Wong Ho; Pawlita, Michael; Zheng, Wei; Yuan, Jian Min; Lan, Qing; Rothman, Nathaniel.

In: International Journal of Cancer, 01.01.2018.

Research output: Contribution to journalArticle

Bassig, BA, Willhauck-Fleckenstein, M, Shu, XO, Koh, WP, Gao, YT, Purdue, MP, Xiang, YB, Adams-Haduch, J, Wang, R, Brenner, N, Waterboer, T, Michel, A, Ji, BT, Hosgood, HD, Rabkin, CS, Yang, G, Wong, JYY, Zhang, J, Hu, W, Seow, WJ, Chow, WH, Pawlita, M, Zheng, W, Yuan, JM, Lan, Q & Rothman, N 2018, 'Serologic markers of viral infection and risk of non-Hodgkin lymphoma: A pooled study of three prospective cohorts in China and Singapore', International Journal of Cancer. https://doi.org/10.1002/ijc.31385
Bassig, Bryan A. ; Willhauck-Fleckenstein, Martina ; Shu, Xiao Ou ; Koh, Woon Puay ; Gao, Yu Tang ; Purdue, Mark P. ; Xiang, Yong Bing ; Adams-Haduch, Jennifer ; Wang, Renwei ; Brenner, Nicole ; Waterboer, Tim ; Michel, Angelika ; Ji, Bu Tian ; Hosgood, Howard D. ; Rabkin, Charles S. ; Yang, Gong ; Wong, Jason Y.Y. ; Zhang, Jinming ; Hu, Wei ; Seow, Wei Jie ; Chow, Wong Ho ; Pawlita, Michael ; Zheng, Wei ; Yuan, Jian Min ; Lan, Qing ; Rothman, Nathaniel. / Serologic markers of viral infection and risk of non-Hodgkin lymphoma : A pooled study of three prospective cohorts in China and Singapore. In: International Journal of Cancer. 2018.
@article{e146ccb46e6f44c1ab659a9550f9d1b0,
title = "Serologic markers of viral infection and risk of non-Hodgkin lymphoma: A pooled study of three prospective cohorts in China and Singapore",
abstract = "Incidence rates of non-Hodgkin lymphoma (NHL) and distributions of certain viruses differ between East Asian and Western populations. There are limited data on associations between serologic markers of multiple viral infections in pre-diagnostic blood and NHL risk in East Asians. We conducted a nested case-control study of 214 NHL cases and 214 matched controls from three population-based prospective cohorts in Shanghai and Singapore. Antibodies against antigens from herpesviruses, Hepatitis B (HBV) and C (HCV) virus and polyomaviruses were measured in plasma or serum using fluorescent bead-based multiplex assays. Conditional logistic regression was used to evaluate associations between antibody levels and NHL risk. An increased risk of NHL was observed for higher compared to lower EA-D (Odds Ratio (OR)=2.04, 95{\%} Confidence Interval (CI)=1.10-3.81; ptrend=0.005) and ZEBRA (OR=2.17, 95{\%} CI=0.96-4.89; ptrend=0.008) Epstein-Barr Virus (EBV) antibodies, as well as for antibody seropositivity against the IE1A human herpesvirus-6 (HHV-6) antigen (OR=1.85, 95{\%} CI=1.04-3.29). An increased NHL risk was also observed for higher compared to lower antibodies against the HBV-HBc and HBe antigens. An increased risk of NHL in relation to EBV and HBV infection in East Asians is consistent with findings in several studies of Western populations, suggesting similar viral risk factors for NHL in these diverse populations with distinct patterns of NHL. The association between HHV-6 antibodies and NHL has not previously been reported in a prospective study in this population and will require replication.",
keywords = "Epstein-Barr virus, Hepatitis, Multiplex serology, Non-Hodgkin lymphoma, Viral antibodies",
author = "Bassig, {Bryan A.} and Martina Willhauck-Fleckenstein and Shu, {Xiao Ou} and Koh, {Woon Puay} and Gao, {Yu Tang} and Purdue, {Mark P.} and Xiang, {Yong Bing} and Jennifer Adams-Haduch and Renwei Wang and Nicole Brenner and Tim Waterboer and Angelika Michel and Ji, {Bu Tian} and Hosgood, {Howard D.} and Rabkin, {Charles S.} and Gong Yang and Wong, {Jason Y.Y.} and Jinming Zhang and Wei Hu and Seow, {Wei Jie} and Chow, {Wong Ho} and Michael Pawlita and Wei Zheng and Yuan, {Jian Min} and Qing Lan and Nathaniel Rothman",
year = "2018",
month = "1",
day = "1",
doi = "10.1002/ijc.31385",
language = "English (US)",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",

}

TY - JOUR

T1 - Serologic markers of viral infection and risk of non-Hodgkin lymphoma

T2 - A pooled study of three prospective cohorts in China and Singapore

AU - Bassig, Bryan A.

AU - Willhauck-Fleckenstein, Martina

AU - Shu, Xiao Ou

AU - Koh, Woon Puay

AU - Gao, Yu Tang

AU - Purdue, Mark P.

AU - Xiang, Yong Bing

AU - Adams-Haduch, Jennifer

AU - Wang, Renwei

AU - Brenner, Nicole

AU - Waterboer, Tim

AU - Michel, Angelika

AU - Ji, Bu Tian

AU - Hosgood, Howard D.

AU - Rabkin, Charles S.

AU - Yang, Gong

AU - Wong, Jason Y.Y.

AU - Zhang, Jinming

AU - Hu, Wei

AU - Seow, Wei Jie

AU - Chow, Wong Ho

AU - Pawlita, Michael

AU - Zheng, Wei

AU - Yuan, Jian Min

AU - Lan, Qing

AU - Rothman, Nathaniel

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Incidence rates of non-Hodgkin lymphoma (NHL) and distributions of certain viruses differ between East Asian and Western populations. There are limited data on associations between serologic markers of multiple viral infections in pre-diagnostic blood and NHL risk in East Asians. We conducted a nested case-control study of 214 NHL cases and 214 matched controls from three population-based prospective cohorts in Shanghai and Singapore. Antibodies against antigens from herpesviruses, Hepatitis B (HBV) and C (HCV) virus and polyomaviruses were measured in plasma or serum using fluorescent bead-based multiplex assays. Conditional logistic regression was used to evaluate associations between antibody levels and NHL risk. An increased risk of NHL was observed for higher compared to lower EA-D (Odds Ratio (OR)=2.04, 95% Confidence Interval (CI)=1.10-3.81; ptrend=0.005) and ZEBRA (OR=2.17, 95% CI=0.96-4.89; ptrend=0.008) Epstein-Barr Virus (EBV) antibodies, as well as for antibody seropositivity against the IE1A human herpesvirus-6 (HHV-6) antigen (OR=1.85, 95% CI=1.04-3.29). An increased NHL risk was also observed for higher compared to lower antibodies against the HBV-HBc and HBe antigens. An increased risk of NHL in relation to EBV and HBV infection in East Asians is consistent with findings in several studies of Western populations, suggesting similar viral risk factors for NHL in these diverse populations with distinct patterns of NHL. The association between HHV-6 antibodies and NHL has not previously been reported in a prospective study in this population and will require replication.

AB - Incidence rates of non-Hodgkin lymphoma (NHL) and distributions of certain viruses differ between East Asian and Western populations. There are limited data on associations between serologic markers of multiple viral infections in pre-diagnostic blood and NHL risk in East Asians. We conducted a nested case-control study of 214 NHL cases and 214 matched controls from three population-based prospective cohorts in Shanghai and Singapore. Antibodies against antigens from herpesviruses, Hepatitis B (HBV) and C (HCV) virus and polyomaviruses were measured in plasma or serum using fluorescent bead-based multiplex assays. Conditional logistic regression was used to evaluate associations between antibody levels and NHL risk. An increased risk of NHL was observed for higher compared to lower EA-D (Odds Ratio (OR)=2.04, 95% Confidence Interval (CI)=1.10-3.81; ptrend=0.005) and ZEBRA (OR=2.17, 95% CI=0.96-4.89; ptrend=0.008) Epstein-Barr Virus (EBV) antibodies, as well as for antibody seropositivity against the IE1A human herpesvirus-6 (HHV-6) antigen (OR=1.85, 95% CI=1.04-3.29). An increased NHL risk was also observed for higher compared to lower antibodies against the HBV-HBc and HBe antigens. An increased risk of NHL in relation to EBV and HBV infection in East Asians is consistent with findings in several studies of Western populations, suggesting similar viral risk factors for NHL in these diverse populations with distinct patterns of NHL. The association between HHV-6 antibodies and NHL has not previously been reported in a prospective study in this population and will require replication.

KW - Epstein-Barr virus

KW - Hepatitis

KW - Multiplex serology

KW - Non-Hodgkin lymphoma

KW - Viral antibodies

UR - http://www.scopus.com/inward/record.url?scp=85044866487&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85044866487&partnerID=8YFLogxK

U2 - 10.1002/ijc.31385

DO - 10.1002/ijc.31385

M3 - Article

C2 - 29574937

AN - SCOPUS:85044866487

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

ER -