Serologic examination of hepatitis B infection and immunization in HIV-positive youth and associated risks

A. S. Rogers, J. C. Lindsey, Donna C. Futterman, B. Zimmer, S. E. Abdalian, L. J. D'Angelo

Research output: Contribution to journalArticle

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Abstract

This seroprevalence report examines serologic evidence of hepatitis B immunization or infection and associated demographic/behavioral factors in adolescent (aged 12-20) subjects enrolled in a nontherapeutic clinical trial at 43 Pediatric AIDS Clinical Trials Group (PACTG) clinical centers. Subjects (n = 94) infected with the human immunodeficiency virus (HIV) through sexual activity were categorized as hepatitis B virus (HBV)-immunized, HBV-infected, or nonimmune by hepatitis B serology performed on specimens collected within the subject's first 48 weeks on study (1993-1995). Sixteen percent of the 94 serologically classified subjects were immunized; 19% HBV-infected; 65% nonimmune. Of the three risk factor scores examined (sociodemographic, sexual, and substance abuse), substance use alone demonstrated a significant difference among groups (despite virtually no reported injecting drug behavior), with the sexual risk score exhibiting marginally significant differences. Logistic regression analysis (restricted to nonimmunized subjects) showed that male-male sexual activity raised the odds of HBV infection by a factor of 5.14 (95% confidence interval [CI]: 1.45-18.23) relative to heterosexual activity; and that for every one point increase on the substance abuse risk scale the odds of infection increased 5% (95% CI: 0.99-1.10). The HBV infection rate in PACTG 220 HIV-positive females is twice United States population-based rates; the rate in PACTG 220 HIV-positive males is nearly seven times higher. Past immunization efforts in this population appear to have been based on sexual activity volume without regard to injecting-drug use in sex partners.

Original languageEnglish (US)
Pages (from-to)651-657
Number of pages7
JournalAIDS Patient Care and STDs
Volume14
Issue number12
DOIs
StatePublished - 2000

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Hepatitis B
Hepatitis B virus
Immunization
Sexual Behavior
HIV
Clinical Trials
Infection
Acquired Immunodeficiency Syndrome
Virus Diseases
Pediatrics
Substance-Related Disorders
Confidence Intervals
Heterosexuality
Sex Offenses
Seroepidemiologic Studies
Serology
Pharmaceutical Preparations
Population
Logistic Models
Regression Analysis

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Leadership and Management
  • Nursing(all)

Cite this

Serologic examination of hepatitis B infection and immunization in HIV-positive youth and associated risks. / Rogers, A. S.; Lindsey, J. C.; Futterman, Donna C.; Zimmer, B.; Abdalian, S. E.; D'Angelo, L. J.

In: AIDS Patient Care and STDs, Vol. 14, No. 12, 2000, p. 651-657.

Research output: Contribution to journalArticle

Rogers, A. S. ; Lindsey, J. C. ; Futterman, Donna C. ; Zimmer, B. ; Abdalian, S. E. ; D'Angelo, L. J. / Serologic examination of hepatitis B infection and immunization in HIV-positive youth and associated risks. In: AIDS Patient Care and STDs. 2000 ; Vol. 14, No. 12. pp. 651-657.
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