Seroepidemiology of the newly found trichodysplasia spinulosa-associated polyomavirus

Tingting Chen, Petri S. Mattila, Tuomas Jartti, Olli Ruuskanen, Maria Söderlund-Venermo, Klaus Hedman

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

Trichodysplasia spinulosa (TS)-associated polyomavirus (TSV) was recently (in 2010) discovered in TS lesions. To investigate the seroprevalence and primary exposure time of this virus, we set up a virus protein (VP1) viruslike particle (VLP)-based immunoglobulin G enzyme immunoassay. The seroprevalence of TSV was 5%, among children aged 1-4 years, rising to 48% at 6-10 years, and 70% among 149 adults. The TSV antibodies did not cross-react with corresponding Merkel cell polyomavirus VLPs, and their reactivity appeared conformational. TSV circulates widely in the human population and primary exposure is extensive in childhood, beginning at age 1-2 years.

Original languageEnglish (US)
Pages (from-to)1523-1526
Number of pages4
JournalJournal of Infectious Diseases
Volume204
Issue number10
DOIs
StatePublished - Nov 15 2011

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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