Seroepidemiology of the newly found trichodysplasia spinulosa-associated polyomavirus

Tingting Chen; Petri S. Mattila; Tuomas Jartti; Olli Ruuskanen; Maria Söderlund-Venermo; Klaus Hedman

doi:10.1093/infdis/jir614

Seroepidemiology of the newly found trichodysplasia spinulosa-associated polyomavirus

Tingting Chen, Petri S. Mattila, Tuomas Jartti, Olli Ruuskanen, Maria Söderlund-Venermo, Klaus Hedman

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Trichodysplasia spinulosa (TS)-associated polyomavirus (TSV) was recently (in 2010) discovered in TS lesions. To investigate the seroprevalence and primary exposure time of this virus, we set up a virus protein (VP1) viruslike particle (VLP)-based immunoglobulin G enzyme immunoassay. The seroprevalence of TSV was 5%, among children aged 1-4 years, rising to 48% at 6-10 years, and 70% among 149 adults. The TSV antibodies did not cross-react with corresponding Merkel cell polyomavirus VLPs, and their reactivity appeared conformational. TSV circulates widely in the human population and primary exposure is extensive in childhood, beginning at age 1-2 years.

Original language	English (US)
Pages (from-to)	1523-1526
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	204
Issue number	10
DOIs	https://doi.org/10.1093/infdis/jir614
State	Published - Nov 15 2011
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/infdis/jir614

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title = "Seroepidemiology of the newly found trichodysplasia spinulosa-associated polyomavirus",

abstract = "Trichodysplasia spinulosa (TS)-associated polyomavirus (TSV) was recently (in 2010) discovered in TS lesions. To investigate the seroprevalence and primary exposure time of this virus, we set up a virus protein (VP1) viruslike particle (VLP)-based immunoglobulin G enzyme immunoassay. The seroprevalence of TSV was 5%, among children aged 1-4 years, rising to 48% at 6-10 years, and 70% among 149 adults. The TSV antibodies did not cross-react with corresponding Merkel cell polyomavirus VLPs, and their reactivity appeared conformational. TSV circulates widely in the human population and primary exposure is extensive in childhood, beginning at age 1-2 years.",

author = "Tingting Chen and Mattila, {Petri S.} and Tuomas Jartti and Olli Ruuskanen and Maria S{\"o}derlund-Venermo and Klaus Hedman",

note = "Funding Information: Financial support. This study was supported by the Helsinki University Central Hospital Research and Education and Research and Development Funds, the Sigrid Jus{\'e}lius Foundation, the Medical Society of Finland, the Academy of Finland (project 1122539), and the Turku University Foundation (O. R.).",

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doi = "10.1093/infdis/jir614",

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AU - Chen, Tingting

AU - Mattila, Petri S.

AU - Jartti, Tuomas

AU - Ruuskanen, Olli

AU - Söderlund-Venermo, Maria

AU - Hedman, Klaus

N1 - Funding Information: Financial support. This study was supported by the Helsinki University Central Hospital Research and Education and Research and Development Funds, the Sigrid Jusélius Foundation, the Medical Society of Finland, the Academy of Finland (project 1122539), and the Turku University Foundation (O. R.).

PY - 2011/11/15

Y1 - 2011/11/15

N2 - Trichodysplasia spinulosa (TS)-associated polyomavirus (TSV) was recently (in 2010) discovered in TS lesions. To investigate the seroprevalence and primary exposure time of this virus, we set up a virus protein (VP1) viruslike particle (VLP)-based immunoglobulin G enzyme immunoassay. The seroprevalence of TSV was 5%, among children aged 1-4 years, rising to 48% at 6-10 years, and 70% among 149 adults. The TSV antibodies did not cross-react with corresponding Merkel cell polyomavirus VLPs, and their reactivity appeared conformational. TSV circulates widely in the human population and primary exposure is extensive in childhood, beginning at age 1-2 years.

AB - Trichodysplasia spinulosa (TS)-associated polyomavirus (TSV) was recently (in 2010) discovered in TS lesions. To investigate the seroprevalence and primary exposure time of this virus, we set up a virus protein (VP1) viruslike particle (VLP)-based immunoglobulin G enzyme immunoassay. The seroprevalence of TSV was 5%, among children aged 1-4 years, rising to 48% at 6-10 years, and 70% among 149 adults. The TSV antibodies did not cross-react with corresponding Merkel cell polyomavirus VLPs, and their reactivity appeared conformational. TSV circulates widely in the human population and primary exposure is extensive in childhood, beginning at age 1-2 years.

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Seroepidemiology of the newly found trichodysplasia spinulosa-associated polyomavirus

Abstract

ASJC Scopus subject areas

UN SDGs

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