Seroepidemiology of the newly found trichodysplasia spinulosa-associated polyomavirus

Tingting Chen, Petri S. Mattila, Tuomas Jartti, Olli Ruuskanen, Maria Söderlund-Venermo, Klaus Hedman

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Trichodysplasia spinulosa (TS)-associated polyomavirus (TSV) was recently (in 2010) discovered in TS lesions. To investigate the seroprevalence and primary exposure time of this virus, we set up a virus protein (VP1) viruslike particle (VLP)-based immunoglobulin G enzyme immunoassay. The seroprevalence of TSV was 5%, among children aged 1-4 years, rising to 48% at 6-10 years, and 70% among 149 adults. The TSV antibodies did not cross-react with corresponding Merkel cell polyomavirus VLPs, and their reactivity appeared conformational. TSV circulates widely in the human population and primary exposure is extensive in childhood, beginning at age 1-2 years.

Original languageEnglish (US)
Pages (from-to)1523-1526
Number of pages4
JournalJournal of Infectious Diseases
Volume204
Issue number10
DOIs
StatePublished - Nov 15 2011
Externally publishedYes

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Polyomavirus
Seroepidemiologic Studies
Merkel cell polyomavirus
Viruses
Immunoenzyme Techniques
Immunoglobulin G
Antibodies
Population
Proteins

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Chen, T., Mattila, P. S., Jartti, T., Ruuskanen, O., Söderlund-Venermo, M., & Hedman, K. (2011). Seroepidemiology of the newly found trichodysplasia spinulosa-associated polyomavirus. Journal of Infectious Diseases, 204(10), 1523-1526. https://doi.org/10.1093/infdis/jir614

Seroepidemiology of the newly found trichodysplasia spinulosa-associated polyomavirus. / Chen, Tingting; Mattila, Petri S.; Jartti, Tuomas; Ruuskanen, Olli; Söderlund-Venermo, Maria; Hedman, Klaus.

In: Journal of Infectious Diseases, Vol. 204, No. 10, 15.11.2011, p. 1523-1526.

Research output: Contribution to journalArticle

Chen, T, Mattila, PS, Jartti, T, Ruuskanen, O, Söderlund-Venermo, M & Hedman, K 2011, 'Seroepidemiology of the newly found trichodysplasia spinulosa-associated polyomavirus', Journal of Infectious Diseases, vol. 204, no. 10, pp. 1523-1526. https://doi.org/10.1093/infdis/jir614
Chen, Tingting ; Mattila, Petri S. ; Jartti, Tuomas ; Ruuskanen, Olli ; Söderlund-Venermo, Maria ; Hedman, Klaus. / Seroepidemiology of the newly found trichodysplasia spinulosa-associated polyomavirus. In: Journal of Infectious Diseases. 2011 ; Vol. 204, No. 10. pp. 1523-1526.
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