Seroconversion rates following COVID-19 vaccination among patients with cancer

Astha Thakkar; Jesus D. Gonzalez-Lugo; Niyati Goradia; Radhika Gali; Lauren C. Shapiro; Kith Pradhan; Shafia Rahman; So Yeon Kim; Brian Ko; R. Alejandro Sica; Noah Kornblum; Lizamarie Bachier-Rodriguez; Margaret McCort; Sanjay Goel; Roman Perez-Soler; Stuart Packer; Joseph Sparano; Benjamin Gartrell; Della Makower; Yitz D. Goldstein; Lucia Wolgast; Amit Verma; Balazs Halmos

doi:10.1016/j.ccell.2021.06.002

Seroconversion rates following COVID-19 vaccination among patients with cancer

Astha Thakkar, Jesus D. Gonzalez-Lugo, Niyati Goradia, Radhika Gali, Lauren C. Shapiro, Kith Pradhan, Shafia Rahman, So Yeon Kim, Brian Ko, R. Alejandro Sica, Noah Kornblum, Lizamarie Bachier-Rodriguez, Margaret McCort, Sanjay Goel, Roman Perez-Soler, Stuart Packer, Joseph Sparano, Benjamin Gartrell, Della Makower, Yitz D. GoldsteinLucia Wolgast, Amit Verma, Balazs Halmos

Research output: Contribution to journal › Article › peer-review

252 Scopus citations

Abstract

As COVID-19 adversely affects patients with cancer, prophylactic strategies are critically needed. Using a validated antibody assay against SARS-CoV-2 spike protein, we determined a high seroconversion rate (94%) in 200 patients with cancer in New York City that had received full dosing with one of the FDA-approved COVID-19 vaccines. On comparison with solid tumors (98%), a significantly lower rate of seroconversion was observed in patients with hematologic malignancies (85%), particularly recipients following highly immunosuppressive therapies such as anti-CD20 therapies (70%) and stem cell transplantation (73%). Patients receiving immune checkpoint inhibitor therapy (97%) or hormonal therapies (100%) demonstrated high seroconversion post vaccination. Patients with prior COVID-19 infection demonstrated higher anti-spike IgG titers post vaccination. Relatively lower IgG titers were observed following vaccination with the adenoviral than with mRNA-based vaccines. These data demonstrate generally high immunogenicity of COVID-19 vaccination in oncology patients and identify immunosuppressed cohorts that need novel vaccination or passive immunization strategies.

Original language	English (US)
Pages (from-to)	1081-1090.e2
Journal	Cancer Cell
Volume	39
Issue number	8
DOIs	https://doi.org/10.1016/j.ccell.2021.06.002
State	Published - Aug 9 2021

Keywords

COVID-19
cancer
hematologi malignancies
vaccine

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ccell.2021.06.002

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Thakkar, A., Gonzalez-Lugo, J. D., Goradia, N., Gali, R., Shapiro, L. C., Pradhan, K., Rahman, S., Kim, S. Y., Ko, B., Sica, R. A., Kornblum, N., Bachier-Rodriguez, L., McCort, M., Goel, S., Perez-Soler, R., Packer, S., Sparano, J., Gartrell, B., Makower, D., ... Halmos, B. (2021). Seroconversion rates following COVID-19 vaccination among patients with cancer. Cancer Cell, 39(8), 1081-1090.e2. https://doi.org/10.1016/j.ccell.2021.06.002

Thakkar, A, Gonzalez-Lugo, JD, Goradia, N, Gali, R, Shapiro, LC, Pradhan, K, Rahman, S, Kim, SY, Ko, B, Sica, RA , Kornblum, N, Bachier-Rodriguez, L, McCort, M, Goel, S, Perez-Soler, R, Packer, S, Sparano, J, Gartrell, B , Makower, D , Goldstein, YD , Wolgast, L , Verma, A & Halmos, B 2021, 'Seroconversion rates following COVID-19 vaccination among patients with cancer', Cancer Cell, vol. 39, no. 8, pp. 1081-1090.e2. https://doi.org/10.1016/j.ccell.2021.06.002

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abstract = "As COVID-19 adversely affects patients with cancer, prophylactic strategies are critically needed. Using a validated antibody assay against SARS-CoV-2 spike protein, we determined a high seroconversion rate (94%) in 200 patients with cancer in New York City that had received full dosing with one of the FDA-approved COVID-19 vaccines. On comparison with solid tumors (98%), a significantly lower rate of seroconversion was observed in patients with hematologic malignancies (85%), particularly recipients following highly immunosuppressive therapies such as anti-CD20 therapies (70%) and stem cell transplantation (73%). Patients receiving immune checkpoint inhibitor therapy (97%) or hormonal therapies (100%) demonstrated high seroconversion post vaccination. Patients with prior COVID-19 infection demonstrated higher anti-spike IgG titers post vaccination. Relatively lower IgG titers were observed following vaccination with the adenoviral than with mRNA-based vaccines. These data demonstrate generally high immunogenicity of COVID-19 vaccination in oncology patients and identify immunosuppressed cohorts that need novel vaccination or passive immunization strategies.",

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doi = "10.1016/j.ccell.2021.06.002",

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AU - Goel, Sanjay

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AU - Packer, Stuart

AU - Sparano, Joseph

AU - Gartrell, Benjamin

AU - Makower, Della

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AU - Wolgast, Lucia

AU - Verma, Amit

AU - Halmos, Balazs

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N2 - As COVID-19 adversely affects patients with cancer, prophylactic strategies are critically needed. Using a validated antibody assay against SARS-CoV-2 spike protein, we determined a high seroconversion rate (94%) in 200 patients with cancer in New York City that had received full dosing with one of the FDA-approved COVID-19 vaccines. On comparison with solid tumors (98%), a significantly lower rate of seroconversion was observed in patients with hematologic malignancies (85%), particularly recipients following highly immunosuppressive therapies such as anti-CD20 therapies (70%) and stem cell transplantation (73%). Patients receiving immune checkpoint inhibitor therapy (97%) or hormonal therapies (100%) demonstrated high seroconversion post vaccination. Patients with prior COVID-19 infection demonstrated higher anti-spike IgG titers post vaccination. Relatively lower IgG titers were observed following vaccination with the adenoviral than with mRNA-based vaccines. These data demonstrate generally high immunogenicity of COVID-19 vaccination in oncology patients and identify immunosuppressed cohorts that need novel vaccination or passive immunization strategies.

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Seroconversion rates following COVID-19 vaccination among patients with cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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