Serial PET studies of human cerebral malignancy with [1-11C]putrescine and [1-11C]2-deoxy-D-glucose

E. Hiesiger, J. S. Fowler, A. P. Wolf, J. Logan, J. D. Brodie, D. McPherson, R. R. MacGregor, D. R. Christman, N. D. Volkow, E. Flamm

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28 Scopus citations


Serial PET measurements of [1-11C]putrescine ([11C]PUT) uptake and glucose metabolic rate (GMR) using [1-11C]2-deoxy-D-glucose ([11C]2DG) were made on eight human subjects with a radiological and, in most cases, pathological diagnosis of primary or metastatic brain tumor. Blood-to-brain influx constants (K(i)) were calculated for [11C]PUT. Tumor uptake of 11C after [11C]PUT injection was unidirectional peaking at 15 min. The mean ± s.d. K(i)s for [11C]PUT for tumor and normal brain tissue were 0.078 ± 0.045 and 0.024 ± 0.007 ml cc-1 min-1, respectively (average of ratio, 3.11) whereas the ratio of GMR for tumor and normal brain tissue was 1.2 ± 0.5. The mean K(i) for four active, high grade astrocytomas was 0.098 ± 0.030 in contrast to 0.027 ± 0.008 ml cc-1 min-1 for two patients with low grade astrocytoma. Active high grade astrocytomas also showed marked CT contrast enhancement and regional glucose hypermetabolism. In one subject with brain metatases, both [11C]PUT and GMR correlated with a declining clinical picture in repeated studies over a 4-mo period. PET studies with [11C]PUT provide a better signal:noise ratio than GMR measurements, are useful for locating small glycolytically hypometabolic tumors and, when used in longitudinal studies in a single subject, appear to provide an index of degree of malignancy.

Original languageEnglish (US)
Pages (from-to)1251-1261
Number of pages11
JournalJournal of Nuclear Medicine
Issue number8
Publication statusPublished - Dec 1 1987
Externally publishedYes


ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Hiesiger, E., Fowler, J. S., Wolf, A. P., Logan, J., Brodie, J. D., McPherson, D., ... Flamm, E. (1987). Serial PET studies of human cerebral malignancy with [1-11C]putrescine and [1-11C]2-deoxy-D-glucose. Journal of Nuclear Medicine, 28(8), 1251-1261.