Serial analysis of gene expression

Technical considerations and applications to cardiovascular biology

Willmar D. Patino, Omar Y. Mian, Paul M. Hwang, Gordon F. Tomaselli

Research output: Contribution to journalShort survey

38 Citations (Scopus)

Abstract

It has been 7 years since serial analysis of gene expression (SAGE) and microarray hybridization techniques were simultaneously introduced to allow the screening of thousands of expressed genes. Both techniques have stood up to the test of time as evidenced by their widespread use, and both have been used for studying cardiovascular diseases. SAGE has been used more extensively to study cancer cells, but it has also been used to examine gene expression in systems as divergent as rice seedlings, yeast, and Caenorhabditis elegans. In this review, a summary of the advances in SAGE technology and its unique attributes and potential applications to the cardiovascular system will be presented.

Original languageEnglish (US)
Pages (from-to)565-569
Number of pages5
JournalCirculation Research
Volume91
Issue number7
DOIs
StatePublished - Oct 4 2002
Externally publishedYes

Fingerprint

Gene Expression
Caenorhabditis elegans
Cardiovascular System
Seedlings
Cardiovascular Diseases
Yeasts
Technology
Genes
Neoplasms
Oryza

Keywords

  • Cardiovascular
  • Expression
  • Gene

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Serial analysis of gene expression : Technical considerations and applications to cardiovascular biology. / Patino, Willmar D.; Mian, Omar Y.; Hwang, Paul M.; Tomaselli, Gordon F.

In: Circulation Research, Vol. 91, No. 7, 04.10.2002, p. 565-569.

Research output: Contribution to journalShort survey

@article{440504fd77ec4b818f8ba986084801d2,
title = "Serial analysis of gene expression: Technical considerations and applications to cardiovascular biology",
abstract = "It has been 7 years since serial analysis of gene expression (SAGE) and microarray hybridization techniques were simultaneously introduced to allow the screening of thousands of expressed genes. Both techniques have stood up to the test of time as evidenced by their widespread use, and both have been used for studying cardiovascular diseases. SAGE has been used more extensively to study cancer cells, but it has also been used to examine gene expression in systems as divergent as rice seedlings, yeast, and Caenorhabditis elegans. In this review, a summary of the advances in SAGE technology and its unique attributes and potential applications to the cardiovascular system will be presented.",
keywords = "Cardiovascular, Expression, Gene",
author = "Patino, {Willmar D.} and Mian, {Omar Y.} and Hwang, {Paul M.} and Tomaselli, {Gordon F.}",
year = "2002",
month = "10",
day = "4",
doi = "10.1161/01.RES.0000036018.76903.18",
language = "English (US)",
volume = "91",
pages = "565--569",
journal = "Circulation Research",
issn = "0009-7330",
publisher = "Lippincott Williams and Wilkins",
number = "7",

}

TY - JOUR

T1 - Serial analysis of gene expression

T2 - Technical considerations and applications to cardiovascular biology

AU - Patino, Willmar D.

AU - Mian, Omar Y.

AU - Hwang, Paul M.

AU - Tomaselli, Gordon F.

PY - 2002/10/4

Y1 - 2002/10/4

N2 - It has been 7 years since serial analysis of gene expression (SAGE) and microarray hybridization techniques were simultaneously introduced to allow the screening of thousands of expressed genes. Both techniques have stood up to the test of time as evidenced by their widespread use, and both have been used for studying cardiovascular diseases. SAGE has been used more extensively to study cancer cells, but it has also been used to examine gene expression in systems as divergent as rice seedlings, yeast, and Caenorhabditis elegans. In this review, a summary of the advances in SAGE technology and its unique attributes and potential applications to the cardiovascular system will be presented.

AB - It has been 7 years since serial analysis of gene expression (SAGE) and microarray hybridization techniques were simultaneously introduced to allow the screening of thousands of expressed genes. Both techniques have stood up to the test of time as evidenced by their widespread use, and both have been used for studying cardiovascular diseases. SAGE has been used more extensively to study cancer cells, but it has also been used to examine gene expression in systems as divergent as rice seedlings, yeast, and Caenorhabditis elegans. In this review, a summary of the advances in SAGE technology and its unique attributes and potential applications to the cardiovascular system will be presented.

KW - Cardiovascular

KW - Expression

KW - Gene

UR - http://www.scopus.com/inward/record.url?scp=0037019949&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037019949&partnerID=8YFLogxK

U2 - 10.1161/01.RES.0000036018.76903.18

DO - 10.1161/01.RES.0000036018.76903.18

M3 - Short survey

VL - 91

SP - 565

EP - 569

JO - Circulation Research

JF - Circulation Research

SN - 0009-7330

IS - 7

ER -