Sequential occurrence of IgA nephropathy and Henoch-Schönlein purpura: support for common pathogenesis

Douglas M. Silverstein; Ira Greifer; Vaughn Folkert; Boyce Bennett; Howard E. Corey; Adrian Spitzer

doi:10.1007/BF00869111

Sequential occurrence of IgA nephropathy and Henoch-Schönlein purpura: support for common pathogenesis

Douglas M. Silverstein, Ira Greifer, Vaughn Folkert, Boyce Bennett, Howard E. Corey, Adrian Spitzer

Medicine

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

We report a patient who developed Henoch-Schönlein purpura (HSP) 13 years after he presented with IgA nephropathy (IgAN). In both HSP and IgAN renal biopsy most commonly reveals focal proliferative glomerulonephritis on light microscopy and immunofluorescence displays mesangial IgA deposits. In addition, patients with HSP or IgAN have elevated serum IgA levels, circulating IgA immune complexes, IgA-bearing lymphocytes, immunoglobulin-producing cells, and binding of IgG to glomerular components of similar molecular weight. The occurrence of both diseases in the same patient or the same families and the presence of immune abnormalities compatible with HSP or IgAN in relatives of patients with these diseases suggest a common pathogenesis.

Original language	English (US)
Pages (from-to)	752-753
Number of pages	2
Journal	Pediatric Nephrology
Volume	8
Issue number	6
DOIs	https://doi.org/10.1007/BF00869111
State	Published - Dec 1994

Keywords

Familial
Henoch-Schönlein purpura
IgA nephropathy
Immunological
Pathogenesis

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Nephrology

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10.1007/BF00869111

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title = "Sequential occurrence of IgA nephropathy and Henoch-Sch{\"o}nlein purpura: support for common pathogenesis",

abstract = "We report a patient who developed Henoch-Sch{\"o}nlein purpura (HSP) 13 years after he presented with IgA nephropathy (IgAN). In both HSP and IgAN renal biopsy most commonly reveals focal proliferative glomerulonephritis on light microscopy and immunofluorescence displays mesangial IgA deposits. In addition, patients with HSP or IgAN have elevated serum IgA levels, circulating IgA immune complexes, IgA-bearing lymphocytes, immunoglobulin-producing cells, and binding of IgG to glomerular components of similar molecular weight. The occurrence of both diseases in the same patient or the same families and the presence of immune abnormalities compatible with HSP or IgAN in relatives of patients with these diseases suggest a common pathogenesis.",

keywords = "Familial, Henoch-Sch{\"o}nlein purpura, IgA nephropathy, Immunological, Pathogenesis",

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T1 - Sequential occurrence of IgA nephropathy and Henoch-Schönlein purpura

T2 - support for common pathogenesis

AU - Silverstein, Douglas M.

AU - Greifer, Ira

AU - Folkert, Vaughn

AU - Bennett, Boyce

AU - Corey, Howard E.

AU - Spitzer, Adrian

PY - 1994/12

Y1 - 1994/12

N2 - We report a patient who developed Henoch-Schönlein purpura (HSP) 13 years after he presented with IgA nephropathy (IgAN). In both HSP and IgAN renal biopsy most commonly reveals focal proliferative glomerulonephritis on light microscopy and immunofluorescence displays mesangial IgA deposits. In addition, patients with HSP or IgAN have elevated serum IgA levels, circulating IgA immune complexes, IgA-bearing lymphocytes, immunoglobulin-producing cells, and binding of IgG to glomerular components of similar molecular weight. The occurrence of both diseases in the same patient or the same families and the presence of immune abnormalities compatible with HSP or IgAN in relatives of patients with these diseases suggest a common pathogenesis.

AB - We report a patient who developed Henoch-Schönlein purpura (HSP) 13 years after he presented with IgA nephropathy (IgAN). In both HSP and IgAN renal biopsy most commonly reveals focal proliferative glomerulonephritis on light microscopy and immunofluorescence displays mesangial IgA deposits. In addition, patients with HSP or IgAN have elevated serum IgA levels, circulating IgA immune complexes, IgA-bearing lymphocytes, immunoglobulin-producing cells, and binding of IgG to glomerular components of similar molecular weight. The occurrence of both diseases in the same patient or the same families and the presence of immune abnormalities compatible with HSP or IgAN in relatives of patients with these diseases suggest a common pathogenesis.

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KW - Immunological

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Sequential occurrence of IgA nephropathy and Henoch-Schönlein purpura: support for common pathogenesis

Abstract

Keywords

ASJC Scopus subject areas

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