Sequencing HNC: Emergence of notch signaling

Curtis R. Pickering; Thomas J. Ow; Jeffrey N. Myers

doi:10.1007/978-1-4614-8815-6_15

Sequencing HNC: Emergence of notch signaling

Curtis R. Pickering, Thomas J. Ow, Jeffrey N. Myers

Otorhinolaryngology - Head & Neck Surgery

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Head and neck cancer is driven by the accumulation of genomic abnormalities. Classically these were characterized by chromosomal alterations and TP53 mutations, but recent sequencing studies have improved our understanding of the full spectrum of mutations in this disease. While a few oncogenes are found to be altered (PIK3CA, HRAS, CCND1), the most frequent events inactivate tumor suppressor genes (TP53, CDKN2A). A surprising new finding was the identification of mutations in the gene NOTCH1. These mutations demonstrate that NOTCH1 is an important tumor suppressor gene in head and neck and other squamous tumors. This has shed new light on the Notch pathway in head and neck cancer progression, and clarified our need to learn more about this pathway in the progression and biology of head and neck cancer.

Original language	English (US)
Title of host publication	Molecular Determinants of Head and Neck Cancer
Publisher	Springer New York
Pages	303-323
Number of pages	21
ISBN (Electronic)	9781461488156
ISBN (Print)	9781461488149
DOIs	https://doi.org/10.1007/978-1-4614-8815-6_15
State	Published - Jan 1 2014

Keywords

Genomics
Head and neck cancer
Notch
Sequencing
Squamous

ASJC Scopus subject areas

Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-1-4614-8815-6_15

Cite this

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abstract = "Head and neck cancer is driven by the accumulation of genomic abnormalities. Classically these were characterized by chromosomal alterations and TP53 mutations, but recent sequencing studies have improved our understanding of the full spectrum of mutations in this disease. While a few oncogenes are found to be altered (PIK3CA, HRAS, CCND1), the most frequent events inactivate tumor suppressor genes (TP53, CDKN2A). A surprising new finding was the identification of mutations in the gene NOTCH1. These mutations demonstrate that NOTCH1 is an important tumor suppressor gene in head and neck and other squamous tumors. This has shed new light on the Notch pathway in head and neck cancer progression, and clarified our need to learn more about this pathway in the progression and biology of head and neck cancer.",

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N2 - Head and neck cancer is driven by the accumulation of genomic abnormalities. Classically these were characterized by chromosomal alterations and TP53 mutations, but recent sequencing studies have improved our understanding of the full spectrum of mutations in this disease. While a few oncogenes are found to be altered (PIK3CA, HRAS, CCND1), the most frequent events inactivate tumor suppressor genes (TP53, CDKN2A). A surprising new finding was the identification of mutations in the gene NOTCH1. These mutations demonstrate that NOTCH1 is an important tumor suppressor gene in head and neck and other squamous tumors. This has shed new light on the Notch pathway in head and neck cancer progression, and clarified our need to learn more about this pathway in the progression and biology of head and neck cancer.

AB - Head and neck cancer is driven by the accumulation of genomic abnormalities. Classically these were characterized by chromosomal alterations and TP53 mutations, but recent sequencing studies have improved our understanding of the full spectrum of mutations in this disease. While a few oncogenes are found to be altered (PIK3CA, HRAS, CCND1), the most frequent events inactivate tumor suppressor genes (TP53, CDKN2A). A surprising new finding was the identification of mutations in the gene NOTCH1. These mutations demonstrate that NOTCH1 is an important tumor suppressor gene in head and neck and other squamous tumors. This has shed new light on the Notch pathway in head and neck cancer progression, and clarified our need to learn more about this pathway in the progression and biology of head and neck cancer.

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Sequencing HNC: Emergence of notch signaling

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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