Separating fact from fiction: The data behind allergies and side effects caused by penicillins, cephalosporins, and carbapenem antibiotics

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6 Citations (Scopus)

Abstract

Antibiotics developed over the past quarter century have greatly improved toxic to therapeutic ratios compared to older agents. This is due to both a wider spectrum of in vitro antibacterial activity and less frequent side effects. In combination with once daily dosing and nearly complete bioavailability of some newer agents, the better risk to benefit ratios have led to empiric antibiotic use in many situations even when bacterial infections are not likely. Many newer antibiotics are not often considered toxic, although their side effects have been documented in medical literature, and several antibiotics that were considered very safe have been removed from the market or their use severely restricted within a relatively short time after their introduction. An understanding of the frequency and mechanism of unintended effects helps physicians minimize them, treat them quickly and effectively when they occur, and even avoid them. Drug interactions and potential adverse effects of β-lactam antibiotics, penicillins, cephalosporins, and carbapenems, are presented.

Original languageEnglish (US)
Pages (from-to)983-988
Number of pages6
JournalCurrent Pharmaceutical Design
Volume9
Issue number12
DOIs
StatePublished - 2003

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Carbapenems
Cephalosporins
Penicillins
Hypersensitivity
Anti-Bacterial Agents
Poisons
Lactams
Drug Interactions
Bacterial Infections
Biological Availability
Physicians
Therapeutics

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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abstract = "Antibiotics developed over the past quarter century have greatly improved toxic to therapeutic ratios compared to older agents. This is due to both a wider spectrum of in vitro antibacterial activity and less frequent side effects. In combination with once daily dosing and nearly complete bioavailability of some newer agents, the better risk to benefit ratios have led to empiric antibiotic use in many situations even when bacterial infections are not likely. Many newer antibiotics are not often considered toxic, although their side effects have been documented in medical literature, and several antibiotics that were considered very safe have been removed from the market or their use severely restricted within a relatively short time after their introduction. An understanding of the frequency and mechanism of unintended effects helps physicians minimize them, treat them quickly and effectively when they occur, and even avoid them. Drug interactions and potential adverse effects of β-lactam antibiotics, penicillins, cephalosporins, and carbapenems, are presented.",
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