Sensory Regulation of C. elegans Male Mate-Searching Behavior

Arantza Barrios, Stephen Nurrish, Scott W. Emmons

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

How do animals integrate internal drives and external environmental cues to coordinate behaviors? We address this question by studying mate-searching behavior in C. elegans. C. elegans males explore their environment in search of mates (hermaphrodites) and will leave food if mating partners are absent [1]. However, when mates and food coincide, male exploratory behavior is suppressed and males are retained on the food source [1]. We show that the drive to explore is stimulated by male-specific neurons in the tail, the ray neurons. Periodic contact with the hermaphrodite detected through ray neurons changes the male's behavior during periods of no contact and prevents the male from leaving the food source. The hermaphrodite signal is conveyed by male-specific interneurons that are postsynaptic to the rays and that send processes to the major integrative center in the head. This study identifies key parts of the neural circuit that regulates a sexual appetitive behavior in C. elegans.

Original languageEnglish (US)
Pages (from-to)1865-1871
Number of pages7
JournalCurrent Biology
Volume18
Issue number23
DOIs
StatePublished - Dec 9 2008

Fingerprint

Appetitive Behavior
searching behavior
Neurons
Food
neurons
Animals
Exploratory Behavior
interneurons
Interneurons
sexual behavior
Networks (circuits)
Sexual Behavior
Cues
tail
Head

Keywords

  • SYSNEURO

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Sensory Regulation of C. elegans Male Mate-Searching Behavior. / Barrios, Arantza; Nurrish, Stephen; Emmons, Scott W.

In: Current Biology, Vol. 18, No. 23, 09.12.2008, p. 1865-1871.

Research output: Contribution to journalArticle

Barrios, Arantza ; Nurrish, Stephen ; Emmons, Scott W. / Sensory Regulation of C. elegans Male Mate-Searching Behavior. In: Current Biology. 2008 ; Vol. 18, No. 23. pp. 1865-1871.
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