Sensory neuropathy associated with Dursban (chlorpyrifos) exposure

J. G. Kaplan, J. Kessler, N. Rosenberg, D. Pack, H. H. Schaumburg

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Chlorpyrifos (Dursban) is an organophosphate insecticide with extensive domestic and agricultural applications. It is regarded as safe for these purposes; one report of neurotoxicity is attributed to massive ingestion in a suicide attempt. We report eight people who developed peripheral neuropathy after exposure to exterminator-applied commercial Dursban; five also experienced memory loss and cognitive slowing. Evaluation failed to reveal other causes of neurologic dysfunction; symptoms recurred in one patient following accidental reexposure. We conclude that environmental contact with chlorpyrifos can cause sensory neuropathy and CNS dysfunction and that this agent should be used with caution.

Original languageEnglish (US)
Pages (from-to)2193-2196
Number of pages4
JournalNeurology
Volume43
Issue number11
StatePublished - Nov 1993

Fingerprint

Chlorpyrifos
Organophosphates
Memory Disorders
Peripheral Nervous System Diseases
Insecticides
Neurologic Manifestations
Suicide
Eating

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Kaplan, J. G., Kessler, J., Rosenberg, N., Pack, D., & Schaumburg, H. H. (1993). Sensory neuropathy associated with Dursban (chlorpyrifos) exposure. Neurology, 43(11), 2193-2196.

Sensory neuropathy associated with Dursban (chlorpyrifos) exposure. / Kaplan, J. G.; Kessler, J.; Rosenberg, N.; Pack, D.; Schaumburg, H. H.

In: Neurology, Vol. 43, No. 11, 11.1993, p. 2193-2196.

Research output: Contribution to journalArticle

Kaplan, JG, Kessler, J, Rosenberg, N, Pack, D & Schaumburg, HH 1993, 'Sensory neuropathy associated with Dursban (chlorpyrifos) exposure', Neurology, vol. 43, no. 11, pp. 2193-2196.
Kaplan JG, Kessler J, Rosenberg N, Pack D, Schaumburg HH. Sensory neuropathy associated with Dursban (chlorpyrifos) exposure. Neurology. 1993 Nov;43(11):2193-2196.
Kaplan, J. G. ; Kessler, J. ; Rosenberg, N. ; Pack, D. ; Schaumburg, H. H. / Sensory neuropathy associated with Dursban (chlorpyrifos) exposure. In: Neurology. 1993 ; Vol. 43, No. 11. pp. 2193-2196.
@article{e7a331ccbb8348c3b398e8fbe184f692,
title = "Sensory neuropathy associated with Dursban (chlorpyrifos) exposure",
abstract = "Chlorpyrifos (Dursban) is an organophosphate insecticide with extensive domestic and agricultural applications. It is regarded as safe for these purposes; one report of neurotoxicity is attributed to massive ingestion in a suicide attempt. We report eight people who developed peripheral neuropathy after exposure to exterminator-applied commercial Dursban; five also experienced memory loss and cognitive slowing. Evaluation failed to reveal other causes of neurologic dysfunction; symptoms recurred in one patient following accidental reexposure. We conclude that environmental contact with chlorpyrifos can cause sensory neuropathy and CNS dysfunction and that this agent should be used with caution.",
author = "Kaplan, {J. G.} and J. Kessler and N. Rosenberg and D. Pack and Schaumburg, {H. H.}",
year = "1993",
month = "11",
language = "English (US)",
volume = "43",
pages = "2193--2196",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "11",

}

TY - JOUR

T1 - Sensory neuropathy associated with Dursban (chlorpyrifos) exposure

AU - Kaplan, J. G.

AU - Kessler, J.

AU - Rosenberg, N.

AU - Pack, D.

AU - Schaumburg, H. H.

PY - 1993/11

Y1 - 1993/11

N2 - Chlorpyrifos (Dursban) is an organophosphate insecticide with extensive domestic and agricultural applications. It is regarded as safe for these purposes; one report of neurotoxicity is attributed to massive ingestion in a suicide attempt. We report eight people who developed peripheral neuropathy after exposure to exterminator-applied commercial Dursban; five also experienced memory loss and cognitive slowing. Evaluation failed to reveal other causes of neurologic dysfunction; symptoms recurred in one patient following accidental reexposure. We conclude that environmental contact with chlorpyrifos can cause sensory neuropathy and CNS dysfunction and that this agent should be used with caution.

AB - Chlorpyrifos (Dursban) is an organophosphate insecticide with extensive domestic and agricultural applications. It is regarded as safe for these purposes; one report of neurotoxicity is attributed to massive ingestion in a suicide attempt. We report eight people who developed peripheral neuropathy after exposure to exterminator-applied commercial Dursban; five also experienced memory loss and cognitive slowing. Evaluation failed to reveal other causes of neurologic dysfunction; symptoms recurred in one patient following accidental reexposure. We conclude that environmental contact with chlorpyrifos can cause sensory neuropathy and CNS dysfunction and that this agent should be used with caution.

UR - http://www.scopus.com/inward/record.url?scp=0027515689&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027515689&partnerID=8YFLogxK

M3 - Article

C2 - 7694187

AN - SCOPUS:0027515689

VL - 43

SP - 2193

EP - 2196

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 11

ER -