Sensory and sympathetic nervous system control of white adipose tissue lipolysis

Timothy J. Bartness, Y. B. Shrestha, C. H. Vaughan, Gary J. Schwartz, C. K. Song

Research output: Contribution to journalArticle

145 Citations (Scopus)

Abstract

Circulating factors are typically invoked to explain bidirectional communication between the CNS and white adipose tissue (WAT). Thus, initiation of lipolysis has been relegated primarily to adrenal medullary secreted catecholamines and the inhibition of lipolysis primarily to pancreatic insulin, whereas signals of body fat levels to the brain have been ascribed to adipokines such as leptin. By contrast, evidence is given for bidirectional communication between brain and WAT occurring via the sympathetic nervous system (SNS) and sensory innervation of this tissue. Using retrograde transneuronal viral tract tracers, the SNS outflow from brain to WAT has been defined. Functionally, sympathetic denervation of WAT blocks lipolysis to a variety of lipolytic stimuli. Using anterograde transneuronal viral tract tracers, the sensory input from WAT to brain has been defined. Functionally, these WAT sensory nerves respond electrophysiologically to increases in WAT SNS drive suggesting a possible neural negative feedback loop to regulate lipolysis.

Original languageEnglish (US)
Pages (from-to)34-43
Number of pages10
JournalMolecular and Cellular Endocrinology
Volume318
Issue number1-2
DOIs
StatePublished - Apr 29 2010

Fingerprint

White Adipose Tissue
Lipolysis
Sympathetic Nervous System
Neurology
Tissue
Brain
Adipokines
Sympathectomy
Leptin
Communication
Catecholamines
Adipose Tissue
Insulin
Fats
Feedback

Keywords

  • Calcitonin gene-related peptide
  • Denervation
  • Norepinephrine
  • Obesity
  • Siberian hamster

ASJC Scopus subject areas

  • Endocrinology
  • Molecular Biology
  • Biochemistry

Cite this

Sensory and sympathetic nervous system control of white adipose tissue lipolysis. / Bartness, Timothy J.; Shrestha, Y. B.; Vaughan, C. H.; Schwartz, Gary J.; Song, C. K.

In: Molecular and Cellular Endocrinology, Vol. 318, No. 1-2, 29.04.2010, p. 34-43.

Research output: Contribution to journalArticle

Bartness, Timothy J. ; Shrestha, Y. B. ; Vaughan, C. H. ; Schwartz, Gary J. ; Song, C. K. / Sensory and sympathetic nervous system control of white adipose tissue lipolysis. In: Molecular and Cellular Endocrinology. 2010 ; Vol. 318, No. 1-2. pp. 34-43.
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