TY - JOUR
T1 - Sensitization in Heart Transplantation
T2 - Emerging Knowledge: A Scientific Statement From the American Heart Association
AU - American Heart Association Heart Failure and Transplantation Committee of the Council on Clinical Cardiology; Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; and Council on Cardiovascular Surgery and Anesthesi
AU - Colvin, Monica M.
AU - Cook, Jennifer L.
AU - Chang, Patricia P.
AU - Hsu, Daphne T.
AU - Kiernan, Michael S.
AU - Kobashigawa, Jon A.
AU - Lindenfeld, Jo Ann
AU - Masri, S. Carolina
AU - Miller, Dylan V.
AU - Rodriguez, E. Rene
AU - Tyan, Dolly B.
AU - Zeevi, Adriana
PY - 2019/3/19
Y1 - 2019/3/19
N2 - Sensitization, defined as the presence of circulating antibodies, presents challenges for heart transplant recipients and physicians. When present, sensitization can limit a transplantation candidate's access to organs, prolong wait time, and, in some cases, exclude the candidate from heart transplantation altogether. The management of sensitization is not yet standardized, and current therapies have not yielded consistent results. Although current strategies involve antibody suppression and removal with intravenous immunoglobulin, plasmapheresis, and antibody therapy, newer strategies with more specific targets are being investigated.
AB - Sensitization, defined as the presence of circulating antibodies, presents challenges for heart transplant recipients and physicians. When present, sensitization can limit a transplantation candidate's access to organs, prolong wait time, and, in some cases, exclude the candidate from heart transplantation altogether. The management of sensitization is not yet standardized, and current therapies have not yielded consistent results. Although current strategies involve antibody suppression and removal with intravenous immunoglobulin, plasmapheresis, and antibody therapy, newer strategies with more specific targets are being investigated.
KW - AHA Scientific Statements
KW - antibodies
KW - heart transplantation
KW - human leukocyte antigen
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U2 - 10.1161/CIR.0000000000000598
DO - 10.1161/CIR.0000000000000598
M3 - Article
C2 - 30776902
AN - SCOPUS:85063261771
SN - 0009-7322
VL - 139
SP - e553-e578
JO - Circulation
JF - Circulation
IS - 12
ER -