Sensitive biomarker of polycyclic aromatic hydrocarbons (PAHs): Urinary 1-hydroxyprene glucuronide in relation to smoking and low ambient levels of exposure

Y. Hu, Z. Zhou, Xiaonan (Nan) Xue, X. Li, J. Fu, B. Cohen, A. A. Melikian, M. Desai, M. S. Tang, X. Huang, N. Roy, J. Sun, P. Nan, Q. Qu

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Abstract

The study was conducted in a Chinese population with occupational or environmental exposures to polycyclic aromatic hydrocarbons (PAHs). A total of 106 subjects were recruited from coke-oven workers (workers), residents in a metropolitan area (residents) and suburban gardeners (gardeners). All subjects were monitored twice for their personal exposures to PAHs. The biological samples were collected for measurements of 1-hydroxypyrene (1-OHP) and cotinine in urine. The geometric means of personal exposure levels of pyrene, benz(a)anthracene (BaA) and benzo(a)pyrene (BaP) in workers were 1.470, 0.978 and 0.805 μg m-3, respectively. The corresponding levels in residents were 0.050, 0.034 and 0.025 μg -3 and those in gardeners were 0.011, 0.020 and 0.008 μg m-3, respectively. The conjugate of 1-OHP with glucuronide (1-OHP-G) is the predominant form of pyrene metabolite in urine and it showed strong associations with exposures not only to pyrene, but also to BaA, BaP and total PAHs. Most importantly, a significant difference in 1-OHP-G was even detected between the subgroups with exposures to BaP at <0.010 and >0.010 but <0.020 μg m-3, suggesting that 1-OHP-G is a good marker that can be used for the risk assessment of BaP exposure at levels currently encountered in ambient air. Furthermore, multiple regression analyses of 1-OHP-G on PAHs exposure indicated that cigarette smoke was a major confounding factor and should be considered and adjusted for while using 1-OHP to estimate PAHs exposure.

Original languageEnglish (US)
Pages (from-to)306-318
Number of pages13
JournalBiomarkers
Volume11
Issue number4
DOIs
StatePublished - Jul 2006

Fingerprint

Polycyclic Aromatic Hydrocarbons
Glucuronides
Biomarkers
Benzo(a)pyrene
Smoking
Urine
Coke
Cotinine
Coke ovens
Environmental Exposure
Occupational Exposure
Metabolites
Smoke
Tobacco Products
Risk assessment
Air
Regression Analysis
Population
pyrene

Keywords

  • 1-hydroxypyrene
  • Biomarkers
  • Environmental exposure
  • Polycyclic aromatic hydrocarbons (PAHs)
  • Urinary metabolites

ASJC Scopus subject areas

  • Biotechnology
  • Toxicology

Cite this

Sensitive biomarker of polycyclic aromatic hydrocarbons (PAHs) : Urinary 1-hydroxyprene glucuronide in relation to smoking and low ambient levels of exposure. / Hu, Y.; Zhou, Z.; Xue, Xiaonan (Nan); Li, X.; Fu, J.; Cohen, B.; Melikian, A. A.; Desai, M.; Tang, M. S.; Huang, X.; Roy, N.; Sun, J.; Nan, P.; Qu, Q.

In: Biomarkers, Vol. 11, No. 4, 07.2006, p. 306-318.

Research output: Contribution to journalArticle

Hu, Y, Zhou, Z, Xue, XN, Li, X, Fu, J, Cohen, B, Melikian, AA, Desai, M, Tang, MS, Huang, X, Roy, N, Sun, J, Nan, P & Qu, Q 2006, 'Sensitive biomarker of polycyclic aromatic hydrocarbons (PAHs): Urinary 1-hydroxyprene glucuronide in relation to smoking and low ambient levels of exposure', Biomarkers, vol. 11, no. 4, pp. 306-318. https://doi.org/10.1080/13547500600626883
Hu, Y. ; Zhou, Z. ; Xue, Xiaonan (Nan) ; Li, X. ; Fu, J. ; Cohen, B. ; Melikian, A. A. ; Desai, M. ; Tang, M. S. ; Huang, X. ; Roy, N. ; Sun, J. ; Nan, P. ; Qu, Q. / Sensitive biomarker of polycyclic aromatic hydrocarbons (PAHs) : Urinary 1-hydroxyprene glucuronide in relation to smoking and low ambient levels of exposure. In: Biomarkers. 2006 ; Vol. 11, No. 4. pp. 306-318.
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abstract = "The study was conducted in a Chinese population with occupational or environmental exposures to polycyclic aromatic hydrocarbons (PAHs). A total of 106 subjects were recruited from coke-oven workers (workers), residents in a metropolitan area (residents) and suburban gardeners (gardeners). All subjects were monitored twice for their personal exposures to PAHs. The biological samples were collected for measurements of 1-hydroxypyrene (1-OHP) and cotinine in urine. The geometric means of personal exposure levels of pyrene, benz(a)anthracene (BaA) and benzo(a)pyrene (BaP) in workers were 1.470, 0.978 and 0.805 μg m-3, respectively. The corresponding levels in residents were 0.050, 0.034 and 0.025 μg -3 and those in gardeners were 0.011, 0.020 and 0.008 μg m-3, respectively. The conjugate of 1-OHP with glucuronide (1-OHP-G) is the predominant form of pyrene metabolite in urine and it showed strong associations with exposures not only to pyrene, but also to BaA, BaP and total PAHs. Most importantly, a significant difference in 1-OHP-G was even detected between the subgroups with exposures to BaP at <0.010 and >0.010 but <0.020 μg m-3, suggesting that 1-OHP-G is a good marker that can be used for the risk assessment of BaP exposure at levels currently encountered in ambient air. Furthermore, multiple regression analyses of 1-OHP-G on PAHs exposure indicated that cigarette smoke was a major confounding factor and should be considered and adjusted for while using 1-OHP to estimate PAHs exposure.",
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AU - Xue, Xiaonan (Nan)

AU - Li, X.

AU - Fu, J.

AU - Cohen, B.

AU - Melikian, A. A.

AU - Desai, M.

AU - Tang, M. S.

AU - Huang, X.

AU - Roy, N.

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AU - Nan, P.

AU - Qu, Q.

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