Abstract
The study was conducted in a Chinese population with occupational or environmental exposures to polycyclic aromatic hydrocarbons (PAHs). A total of 106 subjects were recruited from coke-oven workers (workers), residents in a metropolitan area (residents) and suburban gardeners (gardeners). All subjects were monitored twice for their personal exposures to PAHs. The biological samples were collected for measurements of 1-hydroxypyrene (1-OHP) and cotinine in urine. The geometric means of personal exposure levels of pyrene, benz(a)anthracene (BaA) and benzo(a)pyrene (BaP) in workers were 1.470, 0.978 and 0.805 μg m-3, respectively. The corresponding levels in residents were 0.050, 0.034 and 0.025 μg -3 and those in gardeners were 0.011, 0.020 and 0.008 μg m-3, respectively. The conjugate of 1-OHP with glucuronide (1-OHP-G) is the predominant form of pyrene metabolite in urine and it showed strong associations with exposures not only to pyrene, but also to BaA, BaP and total PAHs. Most importantly, a significant difference in 1-OHP-G was even detected between the subgroups with exposures to BaP at <0.010 and >0.010 but <0.020 μg m-3, suggesting that 1-OHP-G is a good marker that can be used for the risk assessment of BaP exposure at levels currently encountered in ambient air. Furthermore, multiple regression analyses of 1-OHP-G on PAHs exposure indicated that cigarette smoke was a major confounding factor and should be considered and adjusted for while using 1-OHP to estimate PAHs exposure.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 306-318 |
| Number of pages | 13 |
| Journal | Biomarkers |
| Volume | 11 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jul 2006 |
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Keywords
- 1-hydroxypyrene
- Biomarkers
- Environmental exposure
- Polycyclic aromatic hydrocarbons (PAHs)
- Urinary metabolites
ASJC Scopus subject areas
- Biotechnology
- Toxicology
Cite this
Sensitive biomarker of polycyclic aromatic hydrocarbons (PAHs) : Urinary 1-hydroxyprene glucuronide in relation to smoking and low ambient levels of exposure. / Hu, Y.; Zhou, Z.; Xue, Xiaonan (Nan); Li, X.; Fu, J.; Cohen, B.; Melikian, A. A.; Desai, M.; Tang, M. S.; Huang, X.; Roy, N.; Sun, J.; Nan, P.; Qu, Q.
In: Biomarkers, Vol. 11, No. 4, 07.2006, p. 306-318.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sensitive biomarker of polycyclic aromatic hydrocarbons (PAHs)
T2 - Urinary 1-hydroxyprene glucuronide in relation to smoking and low ambient levels of exposure
AU - Hu, Y.
AU - Zhou, Z.
AU - Xue, Xiaonan (Nan)
AU - Li, X.
AU - Fu, J.
AU - Cohen, B.
AU - Melikian, A. A.
AU - Desai, M.
AU - Tang, M. S.
AU - Huang, X.
AU - Roy, N.
AU - Sun, J.
AU - Nan, P.
AU - Qu, Q.
PY - 2006/7
Y1 - 2006/7
N2 - The study was conducted in a Chinese population with occupational or environmental exposures to polycyclic aromatic hydrocarbons (PAHs). A total of 106 subjects were recruited from coke-oven workers (workers), residents in a metropolitan area (residents) and suburban gardeners (gardeners). All subjects were monitored twice for their personal exposures to PAHs. The biological samples were collected for measurements of 1-hydroxypyrene (1-OHP) and cotinine in urine. The geometric means of personal exposure levels of pyrene, benz(a)anthracene (BaA) and benzo(a)pyrene (BaP) in workers were 1.470, 0.978 and 0.805 μg m-3, respectively. The corresponding levels in residents were 0.050, 0.034 and 0.025 μg -3 and those in gardeners were 0.011, 0.020 and 0.008 μg m-3, respectively. The conjugate of 1-OHP with glucuronide (1-OHP-G) is the predominant form of pyrene metabolite in urine and it showed strong associations with exposures not only to pyrene, but also to BaA, BaP and total PAHs. Most importantly, a significant difference in 1-OHP-G was even detected between the subgroups with exposures to BaP at <0.010 and >0.010 but <0.020 μg m-3, suggesting that 1-OHP-G is a good marker that can be used for the risk assessment of BaP exposure at levels currently encountered in ambient air. Furthermore, multiple regression analyses of 1-OHP-G on PAHs exposure indicated that cigarette smoke was a major confounding factor and should be considered and adjusted for while using 1-OHP to estimate PAHs exposure.
AB - The study was conducted in a Chinese population with occupational or environmental exposures to polycyclic aromatic hydrocarbons (PAHs). A total of 106 subjects were recruited from coke-oven workers (workers), residents in a metropolitan area (residents) and suburban gardeners (gardeners). All subjects were monitored twice for their personal exposures to PAHs. The biological samples were collected for measurements of 1-hydroxypyrene (1-OHP) and cotinine in urine. The geometric means of personal exposure levels of pyrene, benz(a)anthracene (BaA) and benzo(a)pyrene (BaP) in workers were 1.470, 0.978 and 0.805 μg m-3, respectively. The corresponding levels in residents were 0.050, 0.034 and 0.025 μg -3 and those in gardeners were 0.011, 0.020 and 0.008 μg m-3, respectively. The conjugate of 1-OHP with glucuronide (1-OHP-G) is the predominant form of pyrene metabolite in urine and it showed strong associations with exposures not only to pyrene, but also to BaA, BaP and total PAHs. Most importantly, a significant difference in 1-OHP-G was even detected between the subgroups with exposures to BaP at <0.010 and >0.010 but <0.020 μg m-3, suggesting that 1-OHP-G is a good marker that can be used for the risk assessment of BaP exposure at levels currently encountered in ambient air. Furthermore, multiple regression analyses of 1-OHP-G on PAHs exposure indicated that cigarette smoke was a major confounding factor and should be considered and adjusted for while using 1-OHP to estimate PAHs exposure.
KW - 1-hydroxypyrene
KW - Biomarkers
KW - Environmental exposure
KW - Polycyclic aromatic hydrocarbons (PAHs)
KW - Urinary metabolites
UR - http://www.scopus.com/inward/record.url?scp=33747332316&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33747332316&partnerID=8YFLogxK
U2 - 10.1080/13547500600626883
DO - 10.1080/13547500600626883
M3 - Article
C2 - 16908438
AN - SCOPUS:33747332316
VL - 11
SP - 306
EP - 318
JO - Biomarkers
JF - Biomarkers
SN - 1354-750X
IS - 4
ER -