Semisynthetic hybrid biopolymers for non-pharmacological intervention of the microcirculation

Beatriz Y.Salazar Vázquez, C. Makena Hightower, Ozlem Yalcin, Seetharama A. Acharya, Marcos Intaglietta

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The microcirculation presents functional organic structures in the range of 1-100 micrometers, commensurate with the upper end of nanotechnology constructs. When devices are designed and deployed to deliver treatment via the circulation they ultimately contend with the smallest dimensions of both healthy and impaired microvessels, particularly the capillary system whose ability to sustain the tissue is assessed by measuring "functional capillary density" (FCD). FCD is directly determined by hydrostatic and osmotic pressures and indirectly by the effect of cardiovascular regulators, particularly the bioavailability of nitric oxide (NO) resulting from fluid mechanical effects and transport in the submicroscopic cell free plasma layer (CFL) located between blood and microvascular wall. Mac-romolecules using colloids as templates that are surface decorated with polyethylene glycol (PEG) become immuno-invisible and can be introduced into the circulation to manipulate the NO environment in blood and the endothelium. PEG-albumin is a class of molecules with novel plasma expansion properties that directly interacts with the microcirculation via CFL related effects. The principal application of this technology is in transfusion medicine and the plasma expanders used to treat blood losses and concomitant effects on microvascu-lar function due to related acute inflammatory conditions and ischemia.

Original languageEnglish (US)
Pages (from-to)540-546
Number of pages7
JournalCurrent Drug Metabolism
Volume14
Issue number5
DOIs
StatePublished - Jun 1 2013

Keywords

  • Cell free layer
  • Functional capillary density
  • Microcirculation
  • PEG-albumin
  • Plasma expanders

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Biochemistry

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  • Cite this

    Vázquez, B. Y. S., Hightower, C. M., Yalcin, O., Acharya, S. A., & Intaglietta, M. (2013). Semisynthetic hybrid biopolymers for non-pharmacological intervention of the microcirculation. Current Drug Metabolism, 14(5), 540-546. https://doi.org/10.2174/13892002113149990011