TY - JOUR
T1 - Semisynthetic hybrid biopolymers for non-pharmacological intervention of the microcirculation
AU - Vázquez, Beatriz Y.Salazar
AU - Hightower, C. Makena
AU - Yalcin, Ozlem
AU - Acharya, Seetharama A.
AU - Intaglietta, Marcos
PY - 2013/6
Y1 - 2013/6
N2 - The microcirculation presents functional organic structures in the range of 1-100 micrometers, commensurate with the upper end of nanotechnology constructs. When devices are designed and deployed to deliver treatment via the circulation they ultimately contend with the smallest dimensions of both healthy and impaired microvessels, particularly the capillary system whose ability to sustain the tissue is assessed by measuring "functional capillary density" (FCD). FCD is directly determined by hydrostatic and osmotic pressures and indirectly by the effect of cardiovascular regulators, particularly the bioavailability of nitric oxide (NO) resulting from fluid mechanical effects and transport in the submicroscopic cell free plasma layer (CFL) located between blood and microvascular wall. Mac-romolecules using colloids as templates that are surface decorated with polyethylene glycol (PEG) become immuno-invisible and can be introduced into the circulation to manipulate the NO environment in blood and the endothelium. PEG-albumin is a class of molecules with novel plasma expansion properties that directly interacts with the microcirculation via CFL related effects. The principal application of this technology is in transfusion medicine and the plasma expanders used to treat blood losses and concomitant effects on microvascu-lar function due to related acute inflammatory conditions and ischemia.
AB - The microcirculation presents functional organic structures in the range of 1-100 micrometers, commensurate with the upper end of nanotechnology constructs. When devices are designed and deployed to deliver treatment via the circulation they ultimately contend with the smallest dimensions of both healthy and impaired microvessels, particularly the capillary system whose ability to sustain the tissue is assessed by measuring "functional capillary density" (FCD). FCD is directly determined by hydrostatic and osmotic pressures and indirectly by the effect of cardiovascular regulators, particularly the bioavailability of nitric oxide (NO) resulting from fluid mechanical effects and transport in the submicroscopic cell free plasma layer (CFL) located between blood and microvascular wall. Mac-romolecules using colloids as templates that are surface decorated with polyethylene glycol (PEG) become immuno-invisible and can be introduced into the circulation to manipulate the NO environment in blood and the endothelium. PEG-albumin is a class of molecules with novel plasma expansion properties that directly interacts with the microcirculation via CFL related effects. The principal application of this technology is in transfusion medicine and the plasma expanders used to treat blood losses and concomitant effects on microvascu-lar function due to related acute inflammatory conditions and ischemia.
KW - Cell free layer
KW - Functional capillary density
KW - Microcirculation
KW - PEG-albumin
KW - Plasma expanders
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U2 - 10.2174/13892002113149990011
DO - 10.2174/13892002113149990011
M3 - Article
C2 - 23687928
AN - SCOPUS:84881625820
SN - 1389-2002
VL - 14
SP - 540
EP - 546
JO - Current Drug Metabolism
JF - Current Drug Metabolism
IS - 5
ER -