Semi-automatic cone beam CT segmentation of in vivo pre-clinical subcutaneous tumours provides an efficient non-invasive alternative for tumour volume measurements

Nils P. Brodin, J. Tang, K. Skalina, T. J. Quinn, Indranil Basu, Chandan Guha, Wolfgang A. Tome

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: To evaluate the feasibility and accuracy of using cone beam CT (CBCT) scans obtained in radiation studies using the small-animal radiation research platform to perform semi-automatic tumour segmentation of pre-clinical tumour volumes. Methods: Volume measurements were evaluated for different anatomical tumour sites, the flank, thigh and dorsum of the hind foot, for a variety of tumour cell lines. The estimated tumour volumes from CBCT and manual calliper measurements using different volume equations were compared with the "gold standard", measured by weighing the tumours following euthanasia and tumour resection. The correlation between tumour volumes estimated with the different methods, compared with the gold standard, was estimated by the Spearman's rank correlation coefficient, root-mean-square deviation and the coefficient of determination. Results: The semi-automatic CBCT volume segmentation performed favourably compared with manual calliper measures for flank tumours ≤2cm<sup>3</sup> and thigh tumours ≤1cm<sup>3</sup>. For tumours >2cm<sup>3</sup> or foot tumours, the CBCT method was not able to accurately segment the tumour volumes and manual calliper measures were superior. Conclusion: We demonstrated that tumour volumes of flank and thigh tumours, obtained as a part of radiation studies using image-guided small-animal irradiators, can be estimated more efficiently and accurately using semiautomatic segmentation from CBCT scans. Advances in knowledge: This is the first study evaluating tumour volume assessment of pre-clinical subcutaneous tumours in different anatomical sites using on-board CBCT imaging. We also compared the accuracy of the CBCT method to manual calliper measures, using various volume calculation equations.

Original languageEnglish (US)
Article number20140776
JournalBritish Journal of Radiology
Volume88
Issue number1050
DOIs
StatePublished - Jun 1 2015

Fingerprint

Tumor Burden
Cone-Beam Computed Tomography
Neoplasms
Thigh
Radiation
Foot
Euthanasia
Nonparametric Statistics
Tumor Cell Line

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

@article{68c126f9c492479082162e11bc88eb31,
title = "Semi-automatic cone beam CT segmentation of in vivo pre-clinical subcutaneous tumours provides an efficient non-invasive alternative for tumour volume measurements",
abstract = "Objective: To evaluate the feasibility and accuracy of using cone beam CT (CBCT) scans obtained in radiation studies using the small-animal radiation research platform to perform semi-automatic tumour segmentation of pre-clinical tumour volumes. Methods: Volume measurements were evaluated for different anatomical tumour sites, the flank, thigh and dorsum of the hind foot, for a variety of tumour cell lines. The estimated tumour volumes from CBCT and manual calliper measurements using different volume equations were compared with the {"}gold standard{"}, measured by weighing the tumours following euthanasia and tumour resection. The correlation between tumour volumes estimated with the different methods, compared with the gold standard, was estimated by the Spearman's rank correlation coefficient, root-mean-square deviation and the coefficient of determination. Results: The semi-automatic CBCT volume segmentation performed favourably compared with manual calliper measures for flank tumours ≤2cm3 and thigh tumours ≤1cm3. For tumours >2cm3 or foot tumours, the CBCT method was not able to accurately segment the tumour volumes and manual calliper measures were superior. Conclusion: We demonstrated that tumour volumes of flank and thigh tumours, obtained as a part of radiation studies using image-guided small-animal irradiators, can be estimated more efficiently and accurately using semiautomatic segmentation from CBCT scans. Advances in knowledge: This is the first study evaluating tumour volume assessment of pre-clinical subcutaneous tumours in different anatomical sites using on-board CBCT imaging. We also compared the accuracy of the CBCT method to manual calliper measures, using various volume calculation equations.",
author = "Brodin, {Nils P.} and J. Tang and K. Skalina and Quinn, {T. J.} and Indranil Basu and Chandan Guha and Tome, {Wolfgang A.}",
year = "2015",
month = "6",
day = "1",
doi = "10.1259/bjr.20140776",
language = "English (US)",
volume = "88",
journal = "British Journal of Radiology",
issn = "0007-1285",
publisher = "British Institute of Radiology",
number = "1050",

}

TY - JOUR

T1 - Semi-automatic cone beam CT segmentation of in vivo pre-clinical subcutaneous tumours provides an efficient non-invasive alternative for tumour volume measurements

AU - Brodin, Nils P.

AU - Tang, J.

AU - Skalina, K.

AU - Quinn, T. J.

AU - Basu, Indranil

AU - Guha, Chandan

AU - Tome, Wolfgang A.

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Objective: To evaluate the feasibility and accuracy of using cone beam CT (CBCT) scans obtained in radiation studies using the small-animal radiation research platform to perform semi-automatic tumour segmentation of pre-clinical tumour volumes. Methods: Volume measurements were evaluated for different anatomical tumour sites, the flank, thigh and dorsum of the hind foot, for a variety of tumour cell lines. The estimated tumour volumes from CBCT and manual calliper measurements using different volume equations were compared with the "gold standard", measured by weighing the tumours following euthanasia and tumour resection. The correlation between tumour volumes estimated with the different methods, compared with the gold standard, was estimated by the Spearman's rank correlation coefficient, root-mean-square deviation and the coefficient of determination. Results: The semi-automatic CBCT volume segmentation performed favourably compared with manual calliper measures for flank tumours ≤2cm3 and thigh tumours ≤1cm3. For tumours >2cm3 or foot tumours, the CBCT method was not able to accurately segment the tumour volumes and manual calliper measures were superior. Conclusion: We demonstrated that tumour volumes of flank and thigh tumours, obtained as a part of radiation studies using image-guided small-animal irradiators, can be estimated more efficiently and accurately using semiautomatic segmentation from CBCT scans. Advances in knowledge: This is the first study evaluating tumour volume assessment of pre-clinical subcutaneous tumours in different anatomical sites using on-board CBCT imaging. We also compared the accuracy of the CBCT method to manual calliper measures, using various volume calculation equations.

AB - Objective: To evaluate the feasibility and accuracy of using cone beam CT (CBCT) scans obtained in radiation studies using the small-animal radiation research platform to perform semi-automatic tumour segmentation of pre-clinical tumour volumes. Methods: Volume measurements were evaluated for different anatomical tumour sites, the flank, thigh and dorsum of the hind foot, for a variety of tumour cell lines. The estimated tumour volumes from CBCT and manual calliper measurements using different volume equations were compared with the "gold standard", measured by weighing the tumours following euthanasia and tumour resection. The correlation between tumour volumes estimated with the different methods, compared with the gold standard, was estimated by the Spearman's rank correlation coefficient, root-mean-square deviation and the coefficient of determination. Results: The semi-automatic CBCT volume segmentation performed favourably compared with manual calliper measures for flank tumours ≤2cm3 and thigh tumours ≤1cm3. For tumours >2cm3 or foot tumours, the CBCT method was not able to accurately segment the tumour volumes and manual calliper measures were superior. Conclusion: We demonstrated that tumour volumes of flank and thigh tumours, obtained as a part of radiation studies using image-guided small-animal irradiators, can be estimated more efficiently and accurately using semiautomatic segmentation from CBCT scans. Advances in knowledge: This is the first study evaluating tumour volume assessment of pre-clinical subcutaneous tumours in different anatomical sites using on-board CBCT imaging. We also compared the accuracy of the CBCT method to manual calliper measures, using various volume calculation equations.

UR - http://www.scopus.com/inward/record.url?scp=84930401648&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930401648&partnerID=8YFLogxK

U2 - 10.1259/bjr.20140776

DO - 10.1259/bjr.20140776

M3 - Article

C2 - 25823502

AN - SCOPUS:84930401648

VL - 88

JO - British Journal of Radiology

JF - British Journal of Radiology

SN - 0007-1285

IS - 1050

M1 - 20140776

ER -