Selective Autophagy: Talking with the UPS

Caroline Park, Ana Maria Cuervo

Research output: Contribution to journalArticlepeer-review

99 Scopus citations


Far from now are the days when investigators raced to identify the proteolytic system responsible for the degradation of their favorite protein. Nowadays, it is well accepted that a given protein can be degraded by different systems depending on factors such as cell type, cellular conditions, or functionality of each proteolytic pathway. The realization of this sharing of substrates among pathways has also helped to unveil deeper levels of communication among the different proteolytic systems. Thus, cells often respond to blockage of one degradative mechanism by upregulating any of the other available pathways. In addition, effectors and regulators of one proteolytic system can be degraded by a different proteolytic pathway that exerts, in this way, a regulatory function. In this mini review, we describe the different levels of cross-talk among autophagic pathways and the ubiquitin/proteasome system. We also provide examples of how this proteolytic communication is used for compensatory purposes in different pathological conditions and discuss the possible therapeutic potential of targeting the modulators of the cross-talk among proteolytic pathways.

Original languageEnglish (US)
Pages (from-to)3-13
Number of pages11
JournalCell Biochemistry and Biophysics
Issue number1
StatePublished - Sep 2013

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology


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