Selective Autophagy in the Pathogenesis of Parkinson's Disease

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter explores various aspects of selective autophagy in the pathogenesis of Parkinson's disease. Compensatory activation of the autophagosomal system in general has been reported in many protein conformational disorders. Expression of huntingtin, the protein found in protein inclusions associated with Huntington's disease, results in upregulation of macroautophagy along with the general stimulation of endosomal-lysosomal activity. Two groups have independently shown that the selective suppression of basal macroautophagy in mouse brain causes diffuse accumulation of ubiquitinated abnormal proteins and ubiquitin-positive inclusions, thereby leading to neuronal toxicity and neurodegeneration. Macroautophagy is initially induced in most of these diseases to protect neurons against abnormal toxic proteins, stress and damaged organelles that may cause cell toxicity and apoptosis. It is observed that pharmacological blockage of the catalytic activities of the proteasome results in upregulation of macroautophagy. It is suggested that macroautophagy can be tracked in cultured cells using recombinant Atg proteins fused to fluorescent proteins which allows identification of autophagosomes, the intracellular compartments directly linked to macroautophagy.

Original languageEnglish (US)
Title of host publicationParkinson's Disease
PublisherElsevier Inc.
Pages409-422
Number of pages14
ISBN (Print)9780123740281
DOIs
StatePublished - 2008

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Autophagy
Parkinson Disease
Up-Regulation
Ubiquitinated Proteins
Proteins
Poisons
Huntington Disease
Proteasome Endopeptidase Complex
Ubiquitin
Heat-Shock Proteins
Recombinant Proteins
Organelles
Cultured Cells
Pharmacology
Apoptosis
Neurons
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Selective Autophagy in the Pathogenesis of Parkinson's Disease. / Kaushik, Susmita; Wong, Esther; Cuervo, Ana Maria.

Parkinson's Disease. Elsevier Inc., 2008. p. 409-422.

Research output: Chapter in Book/Report/Conference proceedingChapter

Kaushik, Susmita ; Wong, Esther ; Cuervo, Ana Maria. / Selective Autophagy in the Pathogenesis of Parkinson's Disease. Parkinson's Disease. Elsevier Inc., 2008. pp. 409-422
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