Selective activation of mesolimbic and mesocortical dopamine metabolism in rat brain by infusion of a stable substance P analogue into the ventral tegmental area

Peter J. Elliott, Jonathan E. Alpert, Michael J. Bannon, Susan D. Iversen

Research output: Contribution to journalArticle

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Abstract

Microinfusion of the metabolically stable substance P (SP) agonist, [pGlu5, MePhe8, Sar9]-SP5-11 (DiMe-C7), into the ventral tegmental area (VTA) of rat brain increased levels of the dopamine (DA) metabolite dihydroxyphenylacetic acid in the prefrontal cortex (+120%) and nucleus accumbens (+30%) but not in other regions of forebrain. In contrast, infusions of DiMe-C7 or SP into the lateral ventricles or microinfusions of SP into VTA failed to elicit increases DOPAC levels in forebrain. DA levels were unaffected by SP or DiMe-C7 regardless of the route administration. These data and previous studies suggest a role for endogenous SP in the modulation of mesocotical and mesolimbic DA neurones.

Original languageEnglish (US)
Pages (from-to)145-147
Number of pages3
JournalBrain Research
Volume363
Issue number1
DOIs
Publication statusPublished - Jan 15 1986
Externally publishedYes

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Keywords

  • [pGlu, MePhe, Sar]-SP (DiMe-C7)
  • dopamine metabolite
  • dopamine neuron
  • footshock stress
  • nucleus accumbens
  • prefrontal cortex
  • substance P
  • ventral tegmental area

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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