Selective activation of mesolimbic and mesocortical dopamine metabolism in rat brain by infusion of a stable substance P analogue into the ventral tegmental area

Peter J. Elliott, Jonathan E. Alpert, Michael J. Bannon, Susan D. Iversen

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Microinfusion of the metabolically stable substance P (SP) agonist, [pGlu5, MePhe8, Sar9]-SP5-11 (DiMe-C7), into the ventral tegmental area (VTA) of rat brain increased levels of the dopamine (DA) metabolite dihydroxyphenylacetic acid in the prefrontal cortex (+120%) and nucleus accumbens (+30%) but not in other regions of forebrain. In contrast, infusions of DiMe-C7 or SP into the lateral ventricles or microinfusions of SP into VTA failed to elicit increases DOPAC levels in forebrain. DA levels were unaffected by SP or DiMe-C7 regardless of the route administration. These data and previous studies suggest a role for endogenous SP in the modulation of mesocotical and mesolimbic DA neurones.

Original languageEnglish (US)
Pages (from-to)145-147
Number of pages3
JournalBrain Research
Volume363
Issue number1
DOIs
StatePublished - Jan 15 1986
Externally publishedYes

Fingerprint

Ventral Tegmental Area
Substance P
Dopamine
Brain
Prosencephalon
3,4-Dihydroxyphenylacetic Acid
Lateral Ventricles
Dopaminergic Neurons
Nucleus Accumbens
Prefrontal Cortex
Acids
pGlu(5)-MePhe(8)-MeGly(9)-substance P (5-11)

Keywords

  • dopamine metabolite
  • dopamine neuron
  • footshock stress
  • nucleus accumbens
  • prefrontal cortex
  • substance P
  • ventral tegmental area
  • [pGlu, MePhe, Sar]-SP (DiMe-C7)

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Selective activation of mesolimbic and mesocortical dopamine metabolism in rat brain by infusion of a stable substance P analogue into the ventral tegmental area. / Elliott, Peter J.; Alpert, Jonathan E.; Bannon, Michael J.; Iversen, Susan D.

In: Brain Research, Vol. 363, No. 1, 15.01.1986, p. 145-147.

Research output: Contribution to journalArticle

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