Selective activation of mesolimbic and mesocortical dopamine metabolism in rat brain by infusion of a stable substance P analogue into the ventral tegmental area

Peter J. Elliott; Jonathan E. Alpert; Michael J. Bannon; Susan D. Iversen

doi:10.1016/0006-8993(86)90667-0

Selective activation of mesolimbic and mesocortical dopamine metabolism in rat brain by infusion of a stable substance P analogue into the ventral tegmental area

Peter J. Elliott, Jonathan E. Alpert, Michael J. Bannon, Susan D. Iversen

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

Microinfusion of the metabolically stable substance P (SP) agonist, [pGlu⁵, MePhe⁸, Sar⁹]-SP_5-11 (DiMe-C7), into the ventral tegmental area (VTA) of rat brain increased levels of the dopamine (DA) metabolite dihydroxyphenylacetic acid in the prefrontal cortex (+120%) and nucleus accumbens (+30%) but not in other regions of forebrain. In contrast, infusions of DiMe-C7 or SP into the lateral ventricles or microinfusions of SP into VTA failed to elicit increases DOPAC levels in forebrain. DA levels were unaffected by SP or DiMe-C7 regardless of the route administration. These data and previous studies suggest a role for endogenous SP in the modulation of mesocotical and mesolimbic DA neurones.

Original language	English (US)
Pages (from-to)	145-147
Number of pages	3
Journal	Brain Research
Volume	363
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(86)90667-0
State	Published - Jan 15 1986
Externally published	Yes

Keywords

[pGlu, MePhe, Sar]-SP (DiMe-C7)
dopamine metabolite
dopamine neuron
footshock stress
nucleus accumbens
prefrontal cortex
substance P
ventral tegmental area

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(86)90667-0

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title = "Selective activation of mesolimbic and mesocortical dopamine metabolism in rat brain by infusion of a stable substance P analogue into the ventral tegmental area",

abstract = "Microinfusion of the metabolically stable substance P (SP) agonist, [pGlu5, MePhe8, Sar9]-SP5-11 (DiMe-C7), into the ventral tegmental area (VTA) of rat brain increased levels of the dopamine (DA) metabolite dihydroxyphenylacetic acid in the prefrontal cortex (+120%) and nucleus accumbens (+30%) but not in other regions of forebrain. In contrast, infusions of DiMe-C7 or SP into the lateral ventricles or microinfusions of SP into VTA failed to elicit increases DOPAC levels in forebrain. DA levels were unaffected by SP or DiMe-C7 regardless of the route administration. These data and previous studies suggest a role for endogenous SP in the modulation of mesocotical and mesolimbic DA neurones.",

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author = "Elliott, {Peter J.} and Alpert, {Jonathan E.} and Bannon, {Michael J.} and Iversen, {Susan D.}",

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T1 - Selective activation of mesolimbic and mesocortical dopamine metabolism in rat brain by infusion of a stable substance P analogue into the ventral tegmental area

AU - Elliott, Peter J.

AU - Alpert, Jonathan E.

AU - Bannon, Michael J.

AU - Iversen, Susan D.

PY - 1986/1/15

Y1 - 1986/1/15

N2 - Microinfusion of the metabolically stable substance P (SP) agonist, [pGlu5, MePhe8, Sar9]-SP5-11 (DiMe-C7), into the ventral tegmental area (VTA) of rat brain increased levels of the dopamine (DA) metabolite dihydroxyphenylacetic acid in the prefrontal cortex (+120%) and nucleus accumbens (+30%) but not in other regions of forebrain. In contrast, infusions of DiMe-C7 or SP into the lateral ventricles or microinfusions of SP into VTA failed to elicit increases DOPAC levels in forebrain. DA levels were unaffected by SP or DiMe-C7 regardless of the route administration. These data and previous studies suggest a role for endogenous SP in the modulation of mesocotical and mesolimbic DA neurones.

AB - Microinfusion of the metabolically stable substance P (SP) agonist, [pGlu5, MePhe8, Sar9]-SP5-11 (DiMe-C7), into the ventral tegmental area (VTA) of rat brain increased levels of the dopamine (DA) metabolite dihydroxyphenylacetic acid in the prefrontal cortex (+120%) and nucleus accumbens (+30%) but not in other regions of forebrain. In contrast, infusions of DiMe-C7 or SP into the lateral ventricles or microinfusions of SP into VTA failed to elicit increases DOPAC levels in forebrain. DA levels were unaffected by SP or DiMe-C7 regardless of the route administration. These data and previous studies suggest a role for endogenous SP in the modulation of mesocotical and mesolimbic DA neurones.

KW - [pGlu, MePhe, Sar]-SP (DiMe-C7)

KW - dopamine metabolite

KW - dopamine neuron

KW - footshock stress

KW - nucleus accumbens

KW - prefrontal cortex

KW - substance P

KW - ventral tegmental area

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Selective activation of mesolimbic and mesocortical dopamine metabolism in rat brain by infusion of a stable substance P analogue into the ventral tegmental area

Abstract

Keywords

ASJC Scopus subject areas

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