Selected rheumatologic and dermatologic manifestations of inflammatory bowel disease

B. Schorr-Lesnick, Lawrence J. Brandt

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

This review focuses on the behavior and pathogenesis of selected dermatologic and rheumatologic manifestations of inflammatory bowel disease. Erythema nodosum, the most common skin lesion, correlates with activity of the bowel disease but not with its duration or extent. Resolution occurs with therapy of inflammatory bowel disease. Pyoderma gangrenosum, the most severe skin lesion, bears little relationship to the activity or extent of the colitis. Therapy is usually supportive, but dapsone and steroids appear promising. Immune and vasculitic mechanisms have been postulated for both skin lesions. Peripheral arthritis usually has its onset with or after the development of colitic symptoms. It worsens with exacerbation of bowel inflammation and responds to treatment of the bowel disease. Immune mechanisms are likely. Spondyloarthropathy usually occurs before the onset of overt intestinal disease. Its course is unrelated to the bowel inflammation, it does not respond to treatment of bowel disease, and it is associated with HLA B27.

Original languageEnglish (US)
Pages (from-to)216-223
Number of pages8
JournalAmerican Journal of Gastroenterology
Volume83
Issue number3
StatePublished - 1988

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Inflammatory Bowel Diseases
Skin
Inflammation
Pyoderma Gangrenosum
Erythema Nodosum
Spondylarthropathies
HLA-B27 Antigen
Intestinal Diseases
Dapsone
Colitis
Arthritis
Steroids
Therapeutics

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Selected rheumatologic and dermatologic manifestations of inflammatory bowel disease. / Schorr-Lesnick, B.; Brandt, Lawrence J.

In: American Journal of Gastroenterology, Vol. 83, No. 3, 1988, p. 216-223.

Research output: Contribution to journalArticle

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