Selected antioxidants and risk of hormone receptor-defined invasive breast cancers among postmenopausal women in the Women's Health Initiative Observational Study

Yan Cui, James M. Shikany, Simin Liu, Yasmeen Shagufta, Thomas E. Rohan

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Background: Few studies have evaluated carotenoids and vitamins C and E in association with the risk of breast cancers defined by estrogen receptor (ER) and progesterone receptor (PR) status. Objective: We examined the associations between dietary and supplemental intakes of these nutrients and risk of breast cancers jointly defined by both ER and PR status among postmenopausal women. Design: Our investigation was conducted in the Women's Health Initiative Observational Study. After following 84 805 women for an average of 7.6 y, 2879 incident invasive breast cancer cases had been ascertained, of whom 2509 had receptor data. We used Cox proportional hazards models to assess the associations of interest. Results: Dietary α-carotene (highest versus lowest quintile: RR = 0.83;95% CL = 0.70, 0.99; P for trend = 0.019), β-carotene (highest versus lowest quintile: RR = 0.78; 95% CL = 0.66, 0.94; P for trend = 0.021), and lycopene (highest versus lowest quintile: RR = 0.85; 95% CL = 0.73, 1.00; P for trend = 0.064) were inversely associated with risk of ER+PR+ breast cancer, but not with other breast cancer groups jointly defined by ER and PR status. Total or supplemental β-carotene and dietary intakes of lutein+zeaxanthin and β-cryptoxanthin were not associated with breast cancers defined by ER and PR status. Vitamin E (regardless of source) and dietary vitamin C were not associated with breast cancer. However, total and supplemental vitamin C intake had weak positive associations with breast cancer overall. Conclusion: Dietary intake of certain carotenoids might be differentially associated with risk of invasive breast cancers jointly defined by ER and PR status among postmenopausal women.

Original languageEnglish (US)
Pages (from-to)1009-1018
Number of pages10
JournalAmerican Journal of Clinical Nutrition
Volume87
Issue number4
StatePublished - Apr 1 2008

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women's health
hormone receptors
Women's Health
observational studies
breast neoplasms
Observational Studies
Antioxidants
Hormones
Progesterone Receptors
Breast Neoplasms
antioxidants
Estrogen Receptors
Carotenoids
carotenes
Ascorbic Acid
ascorbic acid
Vitamin E
vitamin E
food intake
carotenoids

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

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Selected antioxidants and risk of hormone receptor-defined invasive breast cancers among postmenopausal women in the Women's Health Initiative Observational Study. / Cui, Yan; Shikany, James M.; Liu, Simin; Shagufta, Yasmeen; Rohan, Thomas E.

In: American Journal of Clinical Nutrition, Vol. 87, No. 4, 01.04.2008, p. 1009-1018.

Research output: Contribution to journalArticle

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abstract = "Background: Few studies have evaluated carotenoids and vitamins C and E in association with the risk of breast cancers defined by estrogen receptor (ER) and progesterone receptor (PR) status. Objective: We examined the associations between dietary and supplemental intakes of these nutrients and risk of breast cancers jointly defined by both ER and PR status among postmenopausal women. Design: Our investigation was conducted in the Women's Health Initiative Observational Study. After following 84 805 women for an average of 7.6 y, 2879 incident invasive breast cancer cases had been ascertained, of whom 2509 had receptor data. We used Cox proportional hazards models to assess the associations of interest. Results: Dietary α-carotene (highest versus lowest quintile: RR = 0.83;95{\%} CL = 0.70, 0.99; P for trend = 0.019), β-carotene (highest versus lowest quintile: RR = 0.78; 95{\%} CL = 0.66, 0.94; P for trend = 0.021), and lycopene (highest versus lowest quintile: RR = 0.85; 95{\%} CL = 0.73, 1.00; P for trend = 0.064) were inversely associated with risk of ER+PR+ breast cancer, but not with other breast cancer groups jointly defined by ER and PR status. Total or supplemental β-carotene and dietary intakes of lutein+zeaxanthin and β-cryptoxanthin were not associated with breast cancers defined by ER and PR status. Vitamin E (regardless of source) and dietary vitamin C were not associated with breast cancer. However, total and supplemental vitamin C intake had weak positive associations with breast cancer overall. Conclusion: Dietary intake of certain carotenoids might be differentially associated with risk of invasive breast cancers jointly defined by ER and PR status among postmenopausal women.",
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