Seizures early in life

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The immature central nervous system (CNS) should not be considered a miniature of the adult CNS. Seizures and epilepsy affect infants and children more than any other age group. Seizures can manifest themselves differently, depending on age, and can have age-dependent outcomes on development and behavior. Precocious development of excitatory synapses, delayed development of inhibition, and delayed maturation of seizure-modifying circuits are some of the proposed mechanisms that explain the susceptibility to seizures in infants and children. All these factors must be considered when a treatment plan is formulated, including the use of antiepileptic drugs (AEDs) for infants and children. Future directions should include the development of age-specific models and clinical trials to study seizures and epilepsy in people of all ages.

Original languageEnglish (US)
JournalNeurology
Volume55
Issue number5 SUPPL. 1
StatePublished - 2000

Fingerprint

Seizures
Epilepsy
Central Nervous System
Anticonvulsants
Synapses
Age Groups
Clinical Trials
Therapeutics

Keywords

  • Children
  • Developing brain
  • Epilepsy

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Moshe, S. L. (2000). Seizures early in life. Neurology, 55(5 SUPPL. 1).

Seizures early in life. / Moshe, Solomon L.

In: Neurology, Vol. 55, No. 5 SUPPL. 1, 2000.

Research output: Contribution to journalArticle

Moshe, SL 2000, 'Seizures early in life', Neurology, vol. 55, no. 5 SUPPL. 1.
Moshe SL. Seizures early in life. Neurology. 2000;55(5 SUPPL. 1).
Moshe, Solomon L. / Seizures early in life. In: Neurology. 2000 ; Vol. 55, No. 5 SUPPL. 1.
@article{d42513624cb24631a9724fca924766ac,
title = "Seizures early in life",
abstract = "The immature central nervous system (CNS) should not be considered a miniature of the adult CNS. Seizures and epilepsy affect infants and children more than any other age group. Seizures can manifest themselves differently, depending on age, and can have age-dependent outcomes on development and behavior. Precocious development of excitatory synapses, delayed development of inhibition, and delayed maturation of seizure-modifying circuits are some of the proposed mechanisms that explain the susceptibility to seizures in infants and children. All these factors must be considered when a treatment plan is formulated, including the use of antiepileptic drugs (AEDs) for infants and children. Future directions should include the development of age-specific models and clinical trials to study seizures and epilepsy in people of all ages.",
keywords = "Children, Developing brain, Epilepsy",
author = "Moshe, {Solomon L.}",
year = "2000",
language = "English (US)",
volume = "55",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "5 SUPPL. 1",

}

TY - JOUR

T1 - Seizures early in life

AU - Moshe, Solomon L.

PY - 2000

Y1 - 2000

N2 - The immature central nervous system (CNS) should not be considered a miniature of the adult CNS. Seizures and epilepsy affect infants and children more than any other age group. Seizures can manifest themselves differently, depending on age, and can have age-dependent outcomes on development and behavior. Precocious development of excitatory synapses, delayed development of inhibition, and delayed maturation of seizure-modifying circuits are some of the proposed mechanisms that explain the susceptibility to seizures in infants and children. All these factors must be considered when a treatment plan is formulated, including the use of antiepileptic drugs (AEDs) for infants and children. Future directions should include the development of age-specific models and clinical trials to study seizures and epilepsy in people of all ages.

AB - The immature central nervous system (CNS) should not be considered a miniature of the adult CNS. Seizures and epilepsy affect infants and children more than any other age group. Seizures can manifest themselves differently, depending on age, and can have age-dependent outcomes on development and behavior. Precocious development of excitatory synapses, delayed development of inhibition, and delayed maturation of seizure-modifying circuits are some of the proposed mechanisms that explain the susceptibility to seizures in infants and children. All these factors must be considered when a treatment plan is formulated, including the use of antiepileptic drugs (AEDs) for infants and children. Future directions should include the development of age-specific models and clinical trials to study seizures and epilepsy in people of all ages.

KW - Children

KW - Developing brain

KW - Epilepsy

UR - http://www.scopus.com/inward/record.url?scp=0033821956&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033821956&partnerID=8YFLogxK

M3 - Article

C2 - 11001358

AN - SCOPUS:0033821956

VL - 55

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 5 SUPPL. 1

ER -