Secretoneurin releases dopamine from rat striatal slices: A biological effect of a peptide derived from secretogranin II (chromogranin C)

A. Saria, J. Troger, R. Kirchmair, R. Fischer-Colbrie, R. Hogue-Angeletti, H. Winkler

Research output: Contribution to journalArticle

128 Citations (Scopus)

Abstract

Proteolytic processing of secretogranin II (chromogranin C) in brain leads to the formation of a 33-amino acid peptide which we have named secretoneurin. All the properties of secretoneurin are consistent with the concept that this peptide represents a neuropeptide. However, a biological function has not yet been demonstrated. Therefore, we have now investigated whether secretoneurin could alter transmitter release in brain. Slices of rat caudate-putamen were superfused in an in vitro system and dopamine was measured in the superfusate. Secretoneurin dose-dependently increased the outflow of dopamine. This response was abolished in Ca2+-free medium. The secretoneurin-response could also be blocked by preincubation of the peptide with a specific antiserum and was subject to rapid specific and reversible desensitization. This effect on dopamine release constitutes the first discovered biological effect found for a peptide derived from secretogranin II. Thus, secretoneurin can be added to the ever-growing number of neuropeptides.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalNeuroscience
Volume54
Issue number1
DOIs
StatePublished - 1993

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Secretogranin II
Corpus Striatum
Dopamine
Peptides
Neuropeptides
Putamen
Brain
secretoneurin
Immune Sera
Amino Acids

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Secretoneurin releases dopamine from rat striatal slices : A biological effect of a peptide derived from secretogranin II (chromogranin C). / Saria, A.; Troger, J.; Kirchmair, R.; Fischer-Colbrie, R.; Hogue-Angeletti, R.; Winkler, H.

In: Neuroscience, Vol. 54, No. 1, 1993, p. 1-4.

Research output: Contribution to journalArticle

Saria, A. ; Troger, J. ; Kirchmair, R. ; Fischer-Colbrie, R. ; Hogue-Angeletti, R. ; Winkler, H. / Secretoneurin releases dopamine from rat striatal slices : A biological effect of a peptide derived from secretogranin II (chromogranin C). In: Neuroscience. 1993 ; Vol. 54, No. 1. pp. 1-4.
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