Searching for genetic determinants of human aging and longevity: Opportunities and challenges

Jan Vijg, Nathalie Van Orsouw

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


One way of testing possible causal relationships between various functional pathways and aging and longevity processes is to comparatively analyze groups of elderly individuals with select phenotypes for sequence variation in all genes participating in these pathways. Such direct association analysis to identify 'candidate pathways' in aging and longevity is theoretically feasible, with the complete sequence of the human genome known and massive gene annotation projects underway. To find all possible sequence variation of a large number of genes in aging populations, efficient genotyping methods are needed. Here, we describe the use of one such method, two-dimensional gene scanning (TDGS), for screening populations of centenarians and controls for polymorphic variation in the large BRCA1 breast cancer susceptibility gene.

Original languageEnglish (US)
Pages (from-to)195-205
Number of pages11
JournalMechanisms of Ageing and Development
Issue number2-3
StatePublished - 2002
Externally publishedYes


  • Aging and longevity genes
  • BRCA1
  • Direct association studies
  • Single nucleotide polymorphism
  • Two-dimensional gene scanning

ASJC Scopus subject areas

  • Aging
  • Developmental Biology


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