Screening of myopic photorefractive keratectomy in eye bank eyes by computerized videokeratography

Rueben Lim-Bon-Siong, Joseph M. Williams, Sopit Samapunphong, Roy S. Chuck, Jay S. Pepose

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: In contrast to incisional keratotomy, corneas that have undergone photorefractive keratectomy may be difficult to detect by inspection with slitlamp biomicroscopy alone. Eye bank corneas that have undergone high myopic refractive surgical correction could potentially result in substantial postoperative hyperopic correction if used as donor tissue for corneal transplantation. Surface irregularities or displacement of the treated optical zone within the graft in relation to the entrance pupil of the recipient could result in significant induced astigmatism and distortion. This study examines computerized videokeratographic screening of eye bank globes as a strategy for detecting myopic photorefractive keratectomy. Methods: Preoperative and postoperative corneal topographic maps of freshly enucleated human and rabbit eyes that have undergone myopic photorefractive keratectomy with an excimer laser were placed in a globe-fixating device and analyzed using a vertically oriented videokeratoscope. The same system was applied in an actual eye bank setting, and potentially transplantable globes from donors without a history of corneal surgery were analyzed. Results: Computerized videokeratography using a vertically mounted system reliably detected photorefractive keratectomy in 12 of 12 human eye bank corneas treated by excimer photorefractive keratectomy in a range between -1.5 to - 6.0 diopters. This method also detected similar changes on lased rabbit corneas enucleated 6 weeks after excimer surgery. Data processed with the tangential mode yielded a 'bull's-eye' topography pattern reflecting central corneal flattening that was more sensitive in detecting myopic corrections than the conventional axial formula-based color maps. False-positive results were not detected in 96 cadaver globes sequentially screened in the eye bank. Conclusions: Computerized videokeratography represents a feasible method to screen donor globes for myopic photorefractive keratectomy as shown by the in vitro and rabbit models. However, only whole globes and not corneoscleral sections are amenable to processing with this technique. Tangential maps provided greater sensitivity in detecting low myopic corrections than the axial formula-based color maps.

Original languageEnglish (US)
Pages (from-to)617-623
Number of pages7
JournalArchives of Ophthalmology
Volume116
Issue number5
StatePublished - 1998
Externally publishedYes

Fingerprint

Eye Banks
Corneal Topography
Photorefractive Keratectomy
Cornea
Rabbits
Color
Tissue Transplantation
Excimer Lasers
Corneal Transplantation
Astigmatism
Pupil
Cadaver
Transplants
Equipment and Supplies

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Lim-Bon-Siong, R., Williams, J. M., Samapunphong, S., Chuck, R. S., & Pepose, J. S. (1998). Screening of myopic photorefractive keratectomy in eye bank eyes by computerized videokeratography. Archives of Ophthalmology, 116(5), 617-623.

Screening of myopic photorefractive keratectomy in eye bank eyes by computerized videokeratography. / Lim-Bon-Siong, Rueben; Williams, Joseph M.; Samapunphong, Sopit; Chuck, Roy S.; Pepose, Jay S.

In: Archives of Ophthalmology, Vol. 116, No. 5, 1998, p. 617-623.

Research output: Contribution to journalArticle

Lim-Bon-Siong, R, Williams, JM, Samapunphong, S, Chuck, RS & Pepose, JS 1998, 'Screening of myopic photorefractive keratectomy in eye bank eyes by computerized videokeratography', Archives of Ophthalmology, vol. 116, no. 5, pp. 617-623.
Lim-Bon-Siong, Rueben ; Williams, Joseph M. ; Samapunphong, Sopit ; Chuck, Roy S. ; Pepose, Jay S. / Screening of myopic photorefractive keratectomy in eye bank eyes by computerized videokeratography. In: Archives of Ophthalmology. 1998 ; Vol. 116, No. 5. pp. 617-623.
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