Screening for sleep-disordered breathing and excessive daytime sleepiness in adolescent girls with polycystic ovarian syndrome

Kiran Nandalike, Temima Strauss, Chhavi Agarwal, Susan M. Coupey, Sanghun Sin, Swapnil Rajpathak, Hillel W. Cohen, Raanan Arens

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Objective: To determine the prevalence and clinical and metabolic correlates of sleep-disordered breathing (SDB) and excessive daytime sleepiness (EDS) in adolescent girls with polycystic ovarian syndrome (PCOS). Study design: Standardized questionnaires were administered to participants with PCOS and age-, sex-, ethnicity-, and body mass index (BMI) z score-matched controls. Medical records were reviewed for anthropometric and metabolic data. Results: We studied 103 participants with PCOS (16.9 ± 1.5 years) and 90 controls (16.8 ± 1.7 years). Compared with controls, girls with PCOS had a higher prevalence of SDB (45.6% vs 27.8%; P =.01) and EDS (54.4% vs 35.6%; P <.01). Within PCOS, those with SDB had higher BMI z score (2.1 ± 0.5 vs 1.7 ± 0.6; P <.01), higher homeostatic model assessment index (5.1 ± 2.3 vs 4.1 ± 3.5; P <.01), and higher prevalence of the metabolic syndrome (MetS) (42.6% vs 16.1%; P =.003) compared with those without SDB. Similarly, participants with PCOS and EDS had a higher BMI z score (2.0 ± 0.6 vs 1.7 ± 0.6; P =.03), higher homeostatic model assessment index (5.1 ± 2.9 vs 3.8 ± 3.1; P =.01), and higher rate of MetS (39.3% vs. 14.9%; P <.01) compared with those without EDS. MetS was independently associated with SDB (OR, 3.2; 95% CI, 1.0-10.1) and EDS (OR, 4.5; 95% CI, 1.2-16). Conclusions: SDB and EDS are highly prevalent in adolescent girls with PCOS compared with matched controls. The MetS is independently associated with SDB and EDS in this group.

Original languageEnglish (US)
Pages (from-to)591-596
Number of pages6
JournalJournal of Pediatrics
Volume159
Issue number4
DOIs
StatePublished - Oct 1 2011

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Keywords

  • BMI
  • Body mass index
  • EDS
  • Excessive daytime sleepiness
  • HOMA
  • Homeostatic model assessment
  • MetS
  • Metabolic syndrome
  • PCOS
  • Polycystic ovarian syndrome
  • SDB
  • Sleep-disordered breathing

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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