Screening for sleep-disordered breathing and excessive daytime sleepiness in adolescent girls with polycystic ovarian syndrome

Kiran Nandalike, Temima Strauss, Chhavi Agarwal, Susan M. Coupey, Sanghun Sin, Swapnil Rajpathak, Hillel W. Cohen, Raanan Arens

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Objective: To determine the prevalence and clinical and metabolic correlates of sleep-disordered breathing (SDB) and excessive daytime sleepiness (EDS) in adolescent girls with polycystic ovarian syndrome (PCOS). Study design: Standardized questionnaires were administered to participants with PCOS and age-, sex-, ethnicity-, and body mass index (BMI) z score-matched controls. Medical records were reviewed for anthropometric and metabolic data. Results: We studied 103 participants with PCOS (16.9 ± 1.5 years) and 90 controls (16.8 ± 1.7 years). Compared with controls, girls with PCOS had a higher prevalence of SDB (45.6% vs 27.8%; P =.01) and EDS (54.4% vs 35.6%; P <.01). Within PCOS, those with SDB had higher BMI z score (2.1 ± 0.5 vs 1.7 ± 0.6; P <.01), higher homeostatic model assessment index (5.1 ± 2.3 vs 4.1 ± 3.5; P <.01), and higher prevalence of the metabolic syndrome (MetS) (42.6% vs 16.1%; P =.003) compared with those without SDB. Similarly, participants with PCOS and EDS had a higher BMI z score (2.0 ± 0.6 vs 1.7 ± 0.6; P =.03), higher homeostatic model assessment index (5.1 ± 2.9 vs 3.8 ± 3.1; P =.01), and higher rate of MetS (39.3% vs. 14.9%; P <.01) compared with those without EDS. MetS was independently associated with SDB (OR, 3.2; 95% CI, 1.0-10.1) and EDS (OR, 4.5; 95% CI, 1.2-16). Conclusions: SDB and EDS are highly prevalent in adolescent girls with PCOS compared with matched controls. The MetS is independently associated with SDB and EDS in this group.

Original languageEnglish (US)
Pages (from-to)591-596
Number of pages6
JournalJournal of Pediatrics
Volume159
Issue number4
DOIs
StatePublished - Oct 2011

Fingerprint

Polycystic Ovary Syndrome
Sleep Apnea Syndromes
Body Mass Index
Medical Records

Keywords

  • BMI
  • Body mass index
  • EDS
  • Excessive daytime sleepiness
  • HOMA
  • Homeostatic model assessment
  • Metabolic syndrome
  • MetS
  • PCOS
  • Polycystic ovarian syndrome
  • SDB
  • Sleep-disordered breathing

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Screening for sleep-disordered breathing and excessive daytime sleepiness in adolescent girls with polycystic ovarian syndrome. / Nandalike, Kiran; Strauss, Temima; Agarwal, Chhavi; Coupey, Susan M.; Sin, Sanghun; Rajpathak, Swapnil; Cohen, Hillel W.; Arens, Raanan.

In: Journal of Pediatrics, Vol. 159, No. 4, 10.2011, p. 591-596.

Research output: Contribution to journalArticle

Nandalike, Kiran ; Strauss, Temima ; Agarwal, Chhavi ; Coupey, Susan M. ; Sin, Sanghun ; Rajpathak, Swapnil ; Cohen, Hillel W. ; Arens, Raanan. / Screening for sleep-disordered breathing and excessive daytime sleepiness in adolescent girls with polycystic ovarian syndrome. In: Journal of Pediatrics. 2011 ; Vol. 159, No. 4. pp. 591-596.
@article{e29866dc1e7148efbbd0a03bc123b379,
title = "Screening for sleep-disordered breathing and excessive daytime sleepiness in adolescent girls with polycystic ovarian syndrome",
abstract = "Objective: To determine the prevalence and clinical and metabolic correlates of sleep-disordered breathing (SDB) and excessive daytime sleepiness (EDS) in adolescent girls with polycystic ovarian syndrome (PCOS). Study design: Standardized questionnaires were administered to participants with PCOS and age-, sex-, ethnicity-, and body mass index (BMI) z score-matched controls. Medical records were reviewed for anthropometric and metabolic data. Results: We studied 103 participants with PCOS (16.9 ± 1.5 years) and 90 controls (16.8 ± 1.7 years). Compared with controls, girls with PCOS had a higher prevalence of SDB (45.6{\%} vs 27.8{\%}; P =.01) and EDS (54.4{\%} vs 35.6{\%}; P <.01). Within PCOS, those with SDB had higher BMI z score (2.1 ± 0.5 vs 1.7 ± 0.6; P <.01), higher homeostatic model assessment index (5.1 ± 2.3 vs 4.1 ± 3.5; P <.01), and higher prevalence of the metabolic syndrome (MetS) (42.6{\%} vs 16.1{\%}; P =.003) compared with those without SDB. Similarly, participants with PCOS and EDS had a higher BMI z score (2.0 ± 0.6 vs 1.7 ± 0.6; P =.03), higher homeostatic model assessment index (5.1 ± 2.9 vs 3.8 ± 3.1; P =.01), and higher rate of MetS (39.3{\%} vs. 14.9{\%}; P <.01) compared with those without EDS. MetS was independently associated with SDB (OR, 3.2; 95{\%} CI, 1.0-10.1) and EDS (OR, 4.5; 95{\%} CI, 1.2-16). Conclusions: SDB and EDS are highly prevalent in adolescent girls with PCOS compared with matched controls. The MetS is independently associated with SDB and EDS in this group.",
keywords = "BMI, Body mass index, EDS, Excessive daytime sleepiness, HOMA, Homeostatic model assessment, Metabolic syndrome, MetS, PCOS, Polycystic ovarian syndrome, SDB, Sleep-disordered breathing",
author = "Kiran Nandalike and Temima Strauss and Chhavi Agarwal and Coupey, {Susan M.} and Sanghun Sin and Swapnil Rajpathak and Cohen, {Hillel W.} and Raanan Arens",
year = "2011",
month = "10",
doi = "10.1016/j.jpeds.2011.04.027",
language = "English (US)",
volume = "159",
pages = "591--596",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",
number = "4",

}

TY - JOUR

T1 - Screening for sleep-disordered breathing and excessive daytime sleepiness in adolescent girls with polycystic ovarian syndrome

AU - Nandalike, Kiran

AU - Strauss, Temima

AU - Agarwal, Chhavi

AU - Coupey, Susan M.

AU - Sin, Sanghun

AU - Rajpathak, Swapnil

AU - Cohen, Hillel W.

AU - Arens, Raanan

PY - 2011/10

Y1 - 2011/10

N2 - Objective: To determine the prevalence and clinical and metabolic correlates of sleep-disordered breathing (SDB) and excessive daytime sleepiness (EDS) in adolescent girls with polycystic ovarian syndrome (PCOS). Study design: Standardized questionnaires were administered to participants with PCOS and age-, sex-, ethnicity-, and body mass index (BMI) z score-matched controls. Medical records were reviewed for anthropometric and metabolic data. Results: We studied 103 participants with PCOS (16.9 ± 1.5 years) and 90 controls (16.8 ± 1.7 years). Compared with controls, girls with PCOS had a higher prevalence of SDB (45.6% vs 27.8%; P =.01) and EDS (54.4% vs 35.6%; P <.01). Within PCOS, those with SDB had higher BMI z score (2.1 ± 0.5 vs 1.7 ± 0.6; P <.01), higher homeostatic model assessment index (5.1 ± 2.3 vs 4.1 ± 3.5; P <.01), and higher prevalence of the metabolic syndrome (MetS) (42.6% vs 16.1%; P =.003) compared with those without SDB. Similarly, participants with PCOS and EDS had a higher BMI z score (2.0 ± 0.6 vs 1.7 ± 0.6; P =.03), higher homeostatic model assessment index (5.1 ± 2.9 vs 3.8 ± 3.1; P =.01), and higher rate of MetS (39.3% vs. 14.9%; P <.01) compared with those without EDS. MetS was independently associated with SDB (OR, 3.2; 95% CI, 1.0-10.1) and EDS (OR, 4.5; 95% CI, 1.2-16). Conclusions: SDB and EDS are highly prevalent in adolescent girls with PCOS compared with matched controls. The MetS is independently associated with SDB and EDS in this group.

AB - Objective: To determine the prevalence and clinical and metabolic correlates of sleep-disordered breathing (SDB) and excessive daytime sleepiness (EDS) in adolescent girls with polycystic ovarian syndrome (PCOS). Study design: Standardized questionnaires were administered to participants with PCOS and age-, sex-, ethnicity-, and body mass index (BMI) z score-matched controls. Medical records were reviewed for anthropometric and metabolic data. Results: We studied 103 participants with PCOS (16.9 ± 1.5 years) and 90 controls (16.8 ± 1.7 years). Compared with controls, girls with PCOS had a higher prevalence of SDB (45.6% vs 27.8%; P =.01) and EDS (54.4% vs 35.6%; P <.01). Within PCOS, those with SDB had higher BMI z score (2.1 ± 0.5 vs 1.7 ± 0.6; P <.01), higher homeostatic model assessment index (5.1 ± 2.3 vs 4.1 ± 3.5; P <.01), and higher prevalence of the metabolic syndrome (MetS) (42.6% vs 16.1%; P =.003) compared with those without SDB. Similarly, participants with PCOS and EDS had a higher BMI z score (2.0 ± 0.6 vs 1.7 ± 0.6; P =.03), higher homeostatic model assessment index (5.1 ± 2.9 vs 3.8 ± 3.1; P =.01), and higher rate of MetS (39.3% vs. 14.9%; P <.01) compared with those without EDS. MetS was independently associated with SDB (OR, 3.2; 95% CI, 1.0-10.1) and EDS (OR, 4.5; 95% CI, 1.2-16). Conclusions: SDB and EDS are highly prevalent in adolescent girls with PCOS compared with matched controls. The MetS is independently associated with SDB and EDS in this group.

KW - BMI

KW - Body mass index

KW - EDS

KW - Excessive daytime sleepiness

KW - HOMA

KW - Homeostatic model assessment

KW - Metabolic syndrome

KW - MetS

KW - PCOS

KW - Polycystic ovarian syndrome

KW - SDB

KW - Sleep-disordered breathing

UR - http://www.scopus.com/inward/record.url?scp=80052792953&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80052792953&partnerID=8YFLogxK

U2 - 10.1016/j.jpeds.2011.04.027

DO - 10.1016/j.jpeds.2011.04.027

M3 - Article

C2 - 21645911

AN - SCOPUS:80052792953

VL - 159

SP - 591

EP - 596

JO - Journal of Pediatrics

JF - Journal of Pediatrics

SN - 0022-3476

IS - 4

ER -