Screening for predementia AD: Time-dependent operating characteristics of episodic memory tests

Carol A. Derby, Leah C. Burns, Cuiling Wang, Mindy J. Katz, Molly E. Zimmerman, Gilbert L'italien, Zhenchao Guo, Robert M. Berman, Richard B. Lipton

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

Objective: Data from the Einstein Aging Study (EAS) were used to prospectively evaluate the free recall score from the Free andCued Selective Reminding Test (FCSRT-FR) and LogicalMemory I immediate recall (LM-IR) subtest of the WechslerMemory Scale-Revised for prediction of incident Alzheimer disease (AD) dementia among individuals from a community-based cohort with memory complaints. Methods: Analyses included 854 participants, age ≥70 years, who initially had no dementia, and had memory complaints. Clinic evaluations were completed annually and AD dementia was diagnosed using standard criteria (n5 86 cases; average follow-up 4.1 years). Time-dependent receiver operating characteristic analysis was used to evaluate the prognostic ability of FCSRT-FR and LM-IR for incident AD over various durations of follow-up. Results: For identifying those with memory complaints who will develop incident AD dementia over 2-4 years, the FCSRT-FR had better operating characteristics than LM-IR. APOE ε 4 status, age, and education did not affect cut points; however, positive predictive values were higher among APOE ε 4-positive individuals. Conclusions: For follow-up intervals of 2-4 years, the FCSRT-FR is more predictive than the LM-IR for identifying individuals with memory complaints who will develop incident AD. APOE ε 4 status improves positive predictive value, but does not affect the choice of optimal cuts.

Original languageEnglish (US)
Pages (from-to)1307-1314
Number of pages8
JournalNeurology
Volume80
Issue number14
DOIs
StatePublished - Apr 2 2013

ASJC Scopus subject areas

  • Clinical Neurology

Fingerprint Dive into the research topics of 'Screening for predementia AD: Time-dependent operating characteristics of episodic memory tests'. Together they form a unique fingerprint.

  • Cite this