Scarless Wound Healing

Alessandra L. Moore; Clement D. Marshall; Allison Nauta; Hermann P. Lorenz; Michael T. Longaker

doi:10.1016/B978-0-12-809880-6.00005-9

Scarless Wound Healing

Alessandra L. Moore, Clement D. Marshall, Allison Nauta, Hermann P. Lorenz, Michael T. Longaker

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Decades after the discovery of fetal scarless wound healing, therapeutic targets for reducing adult skin fibrosis remain few. Compounding the issue, the number of iatrogenic injuries and patients with multiple comorbidities is mounting, therefore increasing the likelihood of dysfunctional or pathologic wound healing. Also, there is overall growth in clinical expenditures on wound healing. Chapter 5 will contrast the adult and fetal wound healing mechanisms and review current therapeutic and experimental targets focused on reducing adult skin fibrosis and recapitulating the fetal wound healing environment. Through highlighting the differences between fetal and adult healing, scar reduction can be accomplished in the severely afflicted, such as those with contractures, keloids, or burns.

Original language	English (US)
Title of host publication	Principles of Regenerative Medicine
Publisher	Elsevier
Pages	65-92
Number of pages	28
ISBN (Electronic)	9780128098806
ISBN (Print)	9780128098936
DOIs	https://doi.org/10.1016/B978-0-12-809880-6.00005-9
State	Published - Jan 1 2018
Externally published	Yes

Keywords

Burn
Contracture
Fetal wound healing
Hypertrophic scars
Keloids
Scar reduction
Scarless
Skin regeneration
Skin wounds
Wound healing

ASJC Scopus subject areas

General Medicine

Access to Document

10.1016/B978-0-12-809880-6.00005-9

Cite this

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title = "Scarless Wound Healing",

abstract = "Decades after the discovery of fetal scarless wound healing, therapeutic targets for reducing adult skin fibrosis remain few. Compounding the issue, the number of iatrogenic injuries and patients with multiple comorbidities is mounting, therefore increasing the likelihood of dysfunctional or pathologic wound healing. Also, there is overall growth in clinical expenditures on wound healing. Chapter 5 will contrast the adult and fetal wound healing mechanisms and review current therapeutic and experimental targets focused on reducing adult skin fibrosis and recapitulating the fetal wound healing environment. Through highlighting the differences between fetal and adult healing, scar reduction can be accomplished in the severely afflicted, such as those with contractures, keloids, or burns.",

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AU - Moore, Alessandra L.

AU - Marshall, Clement D.

AU - Nauta, Allison

AU - Lorenz, Hermann P.

AU - Longaker, Michael T.

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N2 - Decades after the discovery of fetal scarless wound healing, therapeutic targets for reducing adult skin fibrosis remain few. Compounding the issue, the number of iatrogenic injuries and patients with multiple comorbidities is mounting, therefore increasing the likelihood of dysfunctional or pathologic wound healing. Also, there is overall growth in clinical expenditures on wound healing. Chapter 5 will contrast the adult and fetal wound healing mechanisms and review current therapeutic and experimental targets focused on reducing adult skin fibrosis and recapitulating the fetal wound healing environment. Through highlighting the differences between fetal and adult healing, scar reduction can be accomplished in the severely afflicted, such as those with contractures, keloids, or burns.

AB - Decades after the discovery of fetal scarless wound healing, therapeutic targets for reducing adult skin fibrosis remain few. Compounding the issue, the number of iatrogenic injuries and patients with multiple comorbidities is mounting, therefore increasing the likelihood of dysfunctional or pathologic wound healing. Also, there is overall growth in clinical expenditures on wound healing. Chapter 5 will contrast the adult and fetal wound healing mechanisms and review current therapeutic and experimental targets focused on reducing adult skin fibrosis and recapitulating the fetal wound healing environment. Through highlighting the differences between fetal and adult healing, scar reduction can be accomplished in the severely afflicted, such as those with contractures, keloids, or burns.

KW - Burn

KW - Contracture

KW - Fetal wound healing

KW - Hypertrophic scars

KW - Keloids

KW - Scar reduction

KW - Scarless

KW - Skin regeneration

KW - Skin wounds

KW - Wound healing

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ER -

Scarless Wound Healing

Abstract

Keywords

ASJC Scopus subject areas

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