Scalp EEG Ictal gamma and beta activity during infantile spasms

Evidence of focality

Hiroki Nariai, Jules C. Beal, Aristea S. Galanopoulou, Wenzhu Bi Mowrey, Stephan Bickel, Yoshimi Sogawa, Rana Jehle, Shlomo Shinnar, Solomon L. Moshe

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective: We investigated temporal and spatial characteristics of ictal gamma and beta activity on scalp EEG during spasms in patients with West syndrome (WS) to evaluate potential focal cortical onset. Methods: A total of 1,033 spasms from 34 patients with WS of various etiologies were analyzed on video-electroencephalography (EEG) using time-frequency analysis. Ictal gamma (35–90 Hz) and beta (15–30 Hz) activities were correlated with visual symmetry of spasms, objective EMG (electromyography) analysis, and etiology of WS. Results: Prior to the ictal motor manifestation, focal ictal gamma activity emerged from one hemisphere (71%, 24/34) or from midline (26%, 9/34), and was rarely simultaneously bilateral (3%, 1/34). Focal ictal beta activity emerged from either one hemisphere (68%, 23/34) or from midline (32%, 11/34). Onsets of focal ictal gamma and beta activity were most commonly observed around the parietal areas. Focal ictal gamma activity propagated faster than ictal beta activity to adjacent electrodes (median: 65 vs. 170 msec, p < 0.01), and to contralateral hemisphere (median: 100 vs. 170 msec, p = 0.01). Asymmetric peak amplitude of ictal gamma activity in the centroparietal areas (C3-P3 vs. C4-P4) correlated with asymmetric semiology. On the other hand, most of the visually symmetric spasms showed asymmetry in peak amplitude and interhemispheric onset latency difference in both ictal gamma and beta activity. Significance: Spasms may be a seizure with focal electrographic onset regardless of visual symmetry. Asymmetric involvement of ictal gamma activity to the centroparietal areas may determine the motor manifestations in WS. Scalp EEG ictal gamma and beta activity may be useful to demonstrate localized seizure onset in infants with WS.

Original languageEnglish (US)
Pages (from-to)882-892
Number of pages11
JournalEpilepsia
Volume58
Issue number5
DOIs
StatePublished - May 1 2017

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Infantile Spasms
Scalp
Electroencephalography
Stroke
Spasm
Seizures
Electromyography
Electrodes

Keywords

  • Beta activity
  • Gamma activity
  • High-frequency oscillations
  • Infantile spasms
  • Seizure semiology
  • West syndrome

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Scalp EEG Ictal gamma and beta activity during infantile spasms : Evidence of focality. / Nariai, Hiroki; Beal, Jules C.; Galanopoulou, Aristea S.; Mowrey, Wenzhu Bi; Bickel, Stephan; Sogawa, Yoshimi; Jehle, Rana; Shinnar, Shlomo; Moshe, Solomon L.

In: Epilepsia, Vol. 58, No. 5, 01.05.2017, p. 882-892.

Research output: Contribution to journalArticle

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abstract = "Objective: We investigated temporal and spatial characteristics of ictal gamma and beta activity on scalp EEG during spasms in patients with West syndrome (WS) to evaluate potential focal cortical onset. Methods: A total of 1,033 spasms from 34 patients with WS of various etiologies were analyzed on video-electroencephalography (EEG) using time-frequency analysis. Ictal gamma (35–90 Hz) and beta (15–30 Hz) activities were correlated with visual symmetry of spasms, objective EMG (electromyography) analysis, and etiology of WS. Results: Prior to the ictal motor manifestation, focal ictal gamma activity emerged from one hemisphere (71{\%}, 24/34) or from midline (26{\%}, 9/34), and was rarely simultaneously bilateral (3{\%}, 1/34). Focal ictal beta activity emerged from either one hemisphere (68{\%}, 23/34) or from midline (32{\%}, 11/34). Onsets of focal ictal gamma and beta activity were most commonly observed around the parietal areas. Focal ictal gamma activity propagated faster than ictal beta activity to adjacent electrodes (median: 65 vs. 170 msec, p < 0.01), and to contralateral hemisphere (median: 100 vs. 170 msec, p = 0.01). Asymmetric peak amplitude of ictal gamma activity in the centroparietal areas (C3-P3 vs. C4-P4) correlated with asymmetric semiology. On the other hand, most of the visually symmetric spasms showed asymmetry in peak amplitude and interhemispheric onset latency difference in both ictal gamma and beta activity. Significance: Spasms may be a seizure with focal electrographic onset regardless of visual symmetry. Asymmetric involvement of ictal gamma activity to the centroparietal areas may determine the motor manifestations in WS. Scalp EEG ictal gamma and beta activity may be useful to demonstrate localized seizure onset in infants with WS.",
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AU - Mowrey, Wenzhu Bi

AU - Bickel, Stephan

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