Satellite glial cells as a target for chronic pain therapy

Menachem Hanani, David C. Spray

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Sensory ganglia are essential for the transmission of sensory signals from the periphery to the central nervous system, and abnormal electrical activity in sensory neurons is a major factor in chronic pain. The main type of glial cells in these ganglia are satellite glial cells (SGCs), which surround the sensory neurons tightly. Recently it became evident that SGCs are altered profoundly after nerve injury and that they contribute to chronic pain by influencing neuronal activity. We review the biochemical, pharmacological and physiological changes that SGCs undergo in a variety of pain models, which include: augmented expression of glial fibrillary acidic protein and of proinflammatory cytokines, increased gap junctions, and reduced expression of inward rectifying K<sup>+</sup> channels type K4.1. We discuss how some of these changes can lead to abnormal interactions between SGCs and neurons, and to chronic pain. We propose that these interactions may be utilized as targets for pain therapy. A most attractive option is to reduce the propagation of intercellular calcium waves in the ganglia by agents that inhibit signaling via gap junctions and purinergic P2 receptors.

Original languageEnglish (US)
Title of host publicationPathological Potential of Neuroglia: Possible New Targets for Medical Intervention
PublisherSpringer New York
Pages473-492
Number of pages20
ISBN (Print)9781493909742, 1493909738, 9781493909735
DOIs
StatePublished - Mar 1 2014

Fingerprint

Neuroglia
Chronic Pain
Gap Junctions
Sensory Receptor Cells
Ganglia
Sensory Ganglia
Purinergic P2 Receptors
Therapeutics
Pain
Calcium Signaling
Glial Fibrillary Acidic Protein
Central Nervous System
Pharmacology
Cytokines
Neurons
Wounds and Injuries

Keywords

  • Chronic pain
  • Cytokines
  • GABA
  • Gap junctions
  • Glutamate
  • Pain
  • Pannexin1
  • Purinergic receptors
  • Satellite glial cells
  • Sensory
  • Sensory ganglia

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

Cite this

Hanani, M., & Spray, D. C. (2014). Satellite glial cells as a target for chronic pain therapy. In Pathological Potential of Neuroglia: Possible New Targets for Medical Intervention (pp. 473-492). Springer New York. https://doi.org/10.1007/978-1-4939-0974-2-20

Satellite glial cells as a target for chronic pain therapy. / Hanani, Menachem; Spray, David C.

Pathological Potential of Neuroglia: Possible New Targets for Medical Intervention. Springer New York, 2014. p. 473-492.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hanani, M & Spray, DC 2014, Satellite glial cells as a target for chronic pain therapy. in Pathological Potential of Neuroglia: Possible New Targets for Medical Intervention. Springer New York, pp. 473-492. https://doi.org/10.1007/978-1-4939-0974-2-20
Hanani M, Spray DC. Satellite glial cells as a target for chronic pain therapy. In Pathological Potential of Neuroglia: Possible New Targets for Medical Intervention. Springer New York. 2014. p. 473-492 https://doi.org/10.1007/978-1-4939-0974-2-20
Hanani, Menachem ; Spray, David C. / Satellite glial cells as a target for chronic pain therapy. Pathological Potential of Neuroglia: Possible New Targets for Medical Intervention. Springer New York, 2014. pp. 473-492
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