SARS-CoV-2 coinfection with additional respiratory virus does not predict severe disease: A retrospective cohort study

Sweta Chekuri, Wendy A. Szymczak, D. Yitzchak Goldstein, Priya Nori, Rebecca Marrero Rolon, Brian Spund, Sumeet Singh-Tan, Laurel Mohrmann, Andrei Assa, William N. Southern, Sarah W. Baron

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Background: The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) claimed over 4 million lives by July 2021 and continues to pose a serious public health threat. Objectives: Our retrospective study utilized respiratory pathogen panel (RPP) results in patients with SARS-CoV-2 to determine if coinfection (i.e. SARS-CoV-2 positivity with an additional respiratory virus) was associated with more severe presentation and outcomes. Methods: All patients with negative influenza/respiratory syncytial virus testing who underwent RPP testing within 7 days of a positive SARS-CoV-2 test at a large, academic medical centre in New York were examined. Patients positive for SARS-CoV-2 with a negative RPP were compared with patients positive for SARS-CoV-2 and positive for a virus by RPP in terms of biomarkers, oxygen requirements and severe COVID-19 outcome, as defined by mechanical ventilation or death within 30 days. Results: Of the 306 SARS-CoV-2-positive patients with RPP testing, 14 (4.6%) were positive for a non-influenza virus (coinfected). Compared with the coinfected group, patients positive for SARS-CoV-2 with a negative RPP had higher inflammatory markers and were significantly more likely to be admitted (P=0.01). Severe COVID-19 outcome occurred in 111 (36.3%) patients in the SARS-CoV-2-only group and 3 (21.4%) patients in the coinfected group (P=0.24). Conclusions: Patients infected with SARS-CoV-2 along with a non-influenza respiratory virus had less severe disease on presentation and were more likely to be admitted - but did not have more severe outcomes - than those infected with SARS-CoV-2 alone.

Original languageEnglish (US)
Pages (from-to)III12-III19
JournalJournal of Antimicrobial Chemotherapy
StatePublished - Sep 1 2021

ASJC Scopus subject areas

  • Pharmacology
  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)


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