Sarcolemmal defect and subsarcolemmal lesion in a patient with γ- sarcoglycan deficiency

Mian Li, Dennis W. Dickson, Alfred J. Spiro

Research output: Contribution to journalArticle

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Abstract

We report a case of γ-sarcoglycanopathy with sarcolemmal defects and subsarcolemmal lesions indistinguishable from those in Duchenne muscular dystrophy. Both disorders share certain ultrastructure features that suggest a common pathogenesis related to primary deficiency of transmembrane glycoproteins (e.g., sarcoglycans) or deficiency in dystrophin, which produces a secondary deficiency in sarcoglycans. The lack of transmembrane glycoproteins may contribute to membrane lesions and associated muscle fiber degeneration and necrosis.

Original languageEnglish (US)
Pages (from-to)807-809
Number of pages3
JournalNeurology
Volume50
Issue number3
DOIs
Publication statusPublished - Mar 1998

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ASJC Scopus subject areas

  • Clinical Neurology

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