Sarcolemmal defect and subsarcolemmal lesion in a patient with γ- sarcoglycan deficiency

Mian Li, Dennis W. Dickson, Alfred J. Spiro

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We report a case of γ-sarcoglycanopathy with sarcolemmal defects and subsarcolemmal lesions indistinguishable from those in Duchenne muscular dystrophy. Both disorders share certain ultrastructure features that suggest a common pathogenesis related to primary deficiency of transmembrane glycoproteins (e.g., sarcoglycans) or deficiency in dystrophin, which produces a secondary deficiency in sarcoglycans. The lack of transmembrane glycoproteins may contribute to membrane lesions and associated muscle fiber degeneration and necrosis.

Original languageEnglish (US)
Pages (from-to)807-809
Number of pages3
JournalNeurology
Volume50
Issue number3
StatePublished - Mar 1998

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Sarcoglycans
Sarcoglycanopathies
Glycoproteins
Dystrophin
Duchenne Muscular Dystrophy
Necrosis
Muscles
Membranes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Li, M., Dickson, D. W., & Spiro, A. J. (1998). Sarcolemmal defect and subsarcolemmal lesion in a patient with γ- sarcoglycan deficiency. Neurology, 50(3), 807-809.

Sarcolemmal defect and subsarcolemmal lesion in a patient with γ- sarcoglycan deficiency. / Li, Mian; Dickson, Dennis W.; Spiro, Alfred J.

In: Neurology, Vol. 50, No. 3, 03.1998, p. 807-809.

Research output: Contribution to journalArticle

Li, M, Dickson, DW & Spiro, AJ 1998, 'Sarcolemmal defect and subsarcolemmal lesion in a patient with γ- sarcoglycan deficiency', Neurology, vol. 50, no. 3, pp. 807-809.
Li, Mian ; Dickson, Dennis W. ; Spiro, Alfred J. / Sarcolemmal defect and subsarcolemmal lesion in a patient with γ- sarcoglycan deficiency. In: Neurology. 1998 ; Vol. 50, No. 3. pp. 807-809.
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