"Sarcoid like" granulomatous pulmonary disease in World Trade Center disaster responders

Laura E. Crowley; Robin Herbert; Jacqueline M. Moline; Sylvan Wallenstein; Gauri Shukla; Clyde Schechter; Gwen S. Skloot; Iris Udasin; Benjamin J. Luft; Denise Harrison; Moshe Shapiro; Karen Wong; Henry S. Sacks; Philip J. Landrigan; Alvin S. Teirstein

doi:10.1002/ajim.20924

"Sarcoid like" granulomatous pulmonary disease in World Trade Center disaster responders

Laura E. Crowley, Robin Herbert, Jacqueline M. Moline, Sylvan Wallenstein, Gauri Shukla, Clyde Schechter, Gwen S. Skloot, Iris Udasin, Benjamin J. Luft, Denise Harrison, Moshe Shapiro, Karen Wong, Henry S. Sacks, Philip J. Landrigan, Alvin S. Teirstein

Family and Social Medicine

Research output: Contribution to journal › Article › peer-review

100 Scopus citations

Abstract

Background: More than 20,000 responders have been examined through the World Trade Center (WTC) Medical Monitoring and Treatment Program since September 11, 2001. Studies on WTC firefighters have shown elevated rates of sarcoidosis. The main objective of this study was to report the incidence of "sarcoid like" granulomatous pulmonary disease in other WTC responders. +Methods: Cases of sarcoid like granulomatous pulmonary disease were identified by: patient self-report, physician report and ICD-9 codes. Each case was evaluated by three pulmonologists using the ACCESS criteria and only "definite" cases are reported. +Results: Thirty-eight patients were classified as "definite" cases. Six-year incidence was 192/100,000. The peak annual incidence of 54 per 100,000 person-years occurred between 9/11/2003 and 9/11/2004. Incidence in black responders was nearly double that of white responders. Low FVC was the most common spirometric abnormality. +Conclusions: Sarcoid like granulomatous pulmonary disease is present among the WTC responders. While the incidence is lower than that reported among firefighters, it is higher than expected.

Original language	English (US)
Pages (from-to)	175-184
Number of pages	10
Journal	American Journal of Industrial Medicine
Volume	54
Issue number	3
DOIs	https://doi.org/10.1002/ajim.20924
State	Published - Mar 2011

Keywords

A case control etiologic study of sarcoidosis (ACCESS)
Forced vital capacity (FVC)
Granulomatous disease
Sarcoidosis
World Trade Center (WTC)

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/ajim.20924

Cite this

Crowley, L. E., Herbert, R., Moline, J. M., Wallenstein, S., Shukla, G., Schechter, C., Skloot, G. S., Udasin, I., Luft, B. J., Harrison, D., Shapiro, M., Wong, K., Sacks, H. S., Landrigan, P. J., & Teirstein, A. S. (2011). "Sarcoid like" granulomatous pulmonary disease in World Trade Center disaster responders. American Journal of Industrial Medicine, 54(3), 175-184. https://doi.org/10.1002/ajim.20924

Crowley, LE, Herbert, R, Moline, JM, Wallenstein, S, Shukla, G, Schechter, C, Skloot, GS, Udasin, I, Luft, BJ, Harrison, D, Shapiro, M, Wong, K, Sacks, HS, Landrigan, PJ & Teirstein, AS 2011, '"Sarcoid like" granulomatous pulmonary disease in World Trade Center disaster responders', American Journal of Industrial Medicine, vol. 54, no. 3, pp. 175-184. https://doi.org/10.1002/ajim.20924

@article{543e75b4b1f0433890d2280097b52b5f,

title = "{"}Sarcoid like{"} granulomatous pulmonary disease in World Trade Center disaster responders",

abstract = "Background: More than 20,000 responders have been examined through the World Trade Center (WTC) Medical Monitoring and Treatment Program since September 11, 2001. Studies on WTC firefighters have shown elevated rates of sarcoidosis. The main objective of this study was to report the incidence of {"}sarcoid like{"} granulomatous pulmonary disease in other WTC responders. +Methods: Cases of sarcoid like granulomatous pulmonary disease were identified by: patient self-report, physician report and ICD-9 codes. Each case was evaluated by three pulmonologists using the ACCESS criteria and only {"}definite{"} cases are reported. +Results: Thirty-eight patients were classified as {"}definite{"} cases. Six-year incidence was 192/100,000. The peak annual incidence of 54 per 100,000 person-years occurred between 9/11/2003 and 9/11/2004. Incidence in black responders was nearly double that of white responders. Low FVC was the most common spirometric abnormality. +Conclusions: Sarcoid like granulomatous pulmonary disease is present among the WTC responders. While the incidence is lower than that reported among firefighters, it is higher than expected.",

keywords = "A case control etiologic study of sarcoidosis (ACCESS), Forced vital capacity (FVC), Granulomatous disease, Sarcoidosis, World Trade Center (WTC)",

author = "Crowley, {Laura E.} and Robin Herbert and Moline, {Jacqueline M.} and Sylvan Wallenstein and Gauri Shukla and Clyde Schechter and Skloot, {Gwen S.} and Iris Udasin and Luft, {Benjamin J.} and Denise Harrison and Moshe Shapiro and Karen Wong and Sacks, {Henry S.} and Landrigan, {Philip J.} and Teirstein, {Alvin S.}",

year = "2011",

month = mar,

doi = "10.1002/ajim.20924",

language = "English (US)",

volume = "54",

pages = "175--184",

journal = "American Journal of Industrial Medicine",

issn = "0271-3586",

publisher = "Wiley-Liss Inc.",

number = "3",

}

TY - JOUR

T1 - "Sarcoid like" granulomatous pulmonary disease in World Trade Center disaster responders

AU - Crowley, Laura E.

AU - Herbert, Robin

AU - Moline, Jacqueline M.

AU - Wallenstein, Sylvan

AU - Shukla, Gauri

AU - Schechter, Clyde

AU - Skloot, Gwen S.

AU - Udasin, Iris

AU - Luft, Benjamin J.

AU - Harrison, Denise

AU - Shapiro, Moshe

AU - Wong, Karen

AU - Sacks, Henry S.

AU - Landrigan, Philip J.

AU - Teirstein, Alvin S.

PY - 2011/3

Y1 - 2011/3

N2 - Background: More than 20,000 responders have been examined through the World Trade Center (WTC) Medical Monitoring and Treatment Program since September 11, 2001. Studies on WTC firefighters have shown elevated rates of sarcoidosis. The main objective of this study was to report the incidence of "sarcoid like" granulomatous pulmonary disease in other WTC responders. +Methods: Cases of sarcoid like granulomatous pulmonary disease were identified by: patient self-report, physician report and ICD-9 codes. Each case was evaluated by three pulmonologists using the ACCESS criteria and only "definite" cases are reported. +Results: Thirty-eight patients were classified as "definite" cases. Six-year incidence was 192/100,000. The peak annual incidence of 54 per 100,000 person-years occurred between 9/11/2003 and 9/11/2004. Incidence in black responders was nearly double that of white responders. Low FVC was the most common spirometric abnormality. +Conclusions: Sarcoid like granulomatous pulmonary disease is present among the WTC responders. While the incidence is lower than that reported among firefighters, it is higher than expected.

AB - Background: More than 20,000 responders have been examined through the World Trade Center (WTC) Medical Monitoring and Treatment Program since September 11, 2001. Studies on WTC firefighters have shown elevated rates of sarcoidosis. The main objective of this study was to report the incidence of "sarcoid like" granulomatous pulmonary disease in other WTC responders. +Methods: Cases of sarcoid like granulomatous pulmonary disease were identified by: patient self-report, physician report and ICD-9 codes. Each case was evaluated by three pulmonologists using the ACCESS criteria and only "definite" cases are reported. +Results: Thirty-eight patients were classified as "definite" cases. Six-year incidence was 192/100,000. The peak annual incidence of 54 per 100,000 person-years occurred between 9/11/2003 and 9/11/2004. Incidence in black responders was nearly double that of white responders. Low FVC was the most common spirometric abnormality. +Conclusions: Sarcoid like granulomatous pulmonary disease is present among the WTC responders. While the incidence is lower than that reported among firefighters, it is higher than expected.

KW - A case control etiologic study of sarcoidosis (ACCESS)

KW - Forced vital capacity (FVC)

KW - Granulomatous disease

KW - Sarcoidosis

KW - World Trade Center (WTC)

UR - http://www.scopus.com/inward/record.url?scp=79551643923&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79551643923&partnerID=8YFLogxK

U2 - 10.1002/ajim.20924

DO - 10.1002/ajim.20924

M3 - Article

C2 - 21298693

AN - SCOPUS:79551643923

SN - 0271-3586

VL - 54

SP - 175

EP - 184

JO - American Journal of Industrial Medicine

JF - American Journal of Industrial Medicine

IS - 3

ER -

"Sarcoid like" granulomatous pulmonary disease in World Trade Center disaster responders

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this