Sapien 3 versus Sapien XT prosthetic valves in transcatheter aortic valve implantation: A meta-analysis

Tomo Ando, Alexandros Briasoulis, Anthony A. Holmes, Cynthia C. Taub, Hisato Takagi, Luis Afonso

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Objectives The S3 prosthetic valve was introduced to overcome several issues with its predecessor, the SXT, in transcatheter aortic valve implantation (TAVI), however, the clinical outcomes of this new model are not clearly defined. We performed a meta-analysis to compare the outcomes in Sapien 3 (S3) and Sapien XT (SXT) recipients. Methods A literature search through PUBMED and EMBASE was conducted. Articles that included at least one of the clinical outcomes of interest were included in the meta-analysis: moderate to severe paravalvular regurgitation (PVR), permanent pacemaker implantation (PPI), major vascular complications (MVC), cerebrovascular events (stroke and transient ischemic attack) (CVE), failure rate of device implantation, life-threatening, disabling or major bleeding, need for post-dilation and early all-cause-mortality. Results A total of 9 observational cohort studies were included. S3 was implanted in 945 and SXT in 1553 patients. S3 was associated with a lower incidence of moderate to severe PVR (1.6% vs 6.9%, p 

Original languageEnglish (US)
Pages (from-to)472-478
Number of pages7
JournalInternational Journal of Cardiology
Volume220
DOIs
StatePublished - Oct 1 2016

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Meta-Analysis
Equipment Failure
Transient Ischemic Attack
Observational Studies
Blood Vessels
Dilatation
Cohort Studies
Stroke
Hemorrhage
Mortality
Incidence
Transcatheter Aortic Valve Replacement

Keywords

  • Sapien 3
  • Sapien XT
  • Transcatheter aortic valve implantation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Sapien 3 versus Sapien XT prosthetic valves in transcatheter aortic valve implantation : A meta-analysis. / Ando, Tomo; Briasoulis, Alexandros; Holmes, Anthony A.; Taub, Cynthia C.; Takagi, Hisato; Afonso, Luis.

In: International Journal of Cardiology, Vol. 220, 01.10.2016, p. 472-478.

Research output: Contribution to journalArticle

Ando, Tomo ; Briasoulis, Alexandros ; Holmes, Anthony A. ; Taub, Cynthia C. ; Takagi, Hisato ; Afonso, Luis. / Sapien 3 versus Sapien XT prosthetic valves in transcatheter aortic valve implantation : A meta-analysis. In: International Journal of Cardiology. 2016 ; Vol. 220. pp. 472-478.
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