Sampling Hyperpolarized Molecules Utilizing a 1 Tesla Permanent Magnetic Field

Sui Seng Tee, Valentina DiGialleonardo, Roozbeh Eskandari, Sangmoo Jeong, Kristin L. Granlund, Vesselin Miloushev, Alex J. Poot, Steven Truong, Julio A. Alvarez, Hannah N. Aldeborgh, Kayvan R. Keshari

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Hyperpolarized magnetic resonance spectroscopy (HP MRS) using dynamic nuclear polarization (DNP) is a technique that has greatly enhanced the sensitivity of detecting 13C nuclei. However, the HP MRS polarization decays in the liquid state according to the spin-lattice relaxation time (T1) of the nucleus. Sampling of the signal also destroys polarization, resulting in a limited temporal ability to observe biologically interesting reactions. In this study, we demonstrate that sampling hyperpolarized signals using a permanent magnet at 1 Tesla (1T) is a simple and cost-effective method to increase T1s without sacrificing signal-to-noise. Biologically-relevant information may be obtained with a permanent magnet using enzyme solutions and in whole cells. Of significance, our findings indicate that changes in pyruvate metabolism can also be quantified in a xenograft model at this field strength.

Original languageEnglish (US)
Article number32846
JournalScientific reports
Volume6
DOIs
StatePublished - Sep 6 2016
Externally publishedYes

ASJC Scopus subject areas

  • General

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