Sam68 Enables Metabotropic Glutamate Receptor-Dependent LTD in Distal Dendritic Regions of CA1 Hippocampal Neurons

Matthew E. Klein, Thomas J. Younts, Carmen Freire Cobo, Adina R. Buxbaum, Jonathan Aow, Hediye Erdjument-Bromage, Stéphane Richard, Roberto Malinow, Thomas A. Neubert, Robert H. Singer, Pablo E. Castillo, Bryen A. Jordan

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Although local translation in neuronal dendrites is well documented, there is little evidence for corresponding effects on local synaptic function. Klein et al. demonstrate that Sam68 is required for Arc protein synthesis at distal dendritic regions and is required for synaptic plasticity exclusively at distal dendrites of hippocampal pyramidal neurons.

Original languageEnglish (US)
Pages (from-to)1789-1799.e6
JournalCell Reports
Volume29
Issue number7
DOIs
StatePublished - Nov 12 2019

Keywords

  • Arc
  • Arg3.1
  • interactome
  • isobaric tags
  • local translation
  • mRNA localization
  • proteomic
  • RNA-binding proteins
  • RNAscope

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Klein, M. E., Younts, T. J., Cobo, C. F., Buxbaum, A. R., Aow, J., Erdjument-Bromage, H., Richard, S., Malinow, R., Neubert, T. A., Singer, R. H., Castillo, P. E., & Jordan, B. A. (2019). Sam68 Enables Metabotropic Glutamate Receptor-Dependent LTD in Distal Dendritic Regions of CA1 Hippocampal Neurons. Cell Reports, 29(7), 1789-1799.e6. https://doi.org/10.1016/j.celrep.2019.10.030