Abstract
Although local translation in neuronal dendrites is well documented, there is little evidence for corresponding effects on local synaptic function. Klein et al. demonstrate that Sam68 is required for Arc protein synthesis at distal dendritic regions and is required for synaptic plasticity exclusively at distal dendrites of hippocampal pyramidal neurons.
Original language | English (US) |
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Pages (from-to) | 1789-1799.e6 |
Journal | Cell Reports |
Volume | 29 |
Issue number | 7 |
DOIs | |
State | Published - Nov 12 2019 |
Keywords
- Arc
- Arg3.1
- RNA-binding proteins
- RNAscope
- interactome
- isobaric tags
- local translation
- mRNA localization
- proteomic
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology