TY - JOUR
T1 - Salivary mucoepidermoid carcinoma revisited
AU - Coca-Pelaz, Andrés
AU - Rodrigo, Juan P.
AU - Triantafyllou, Asterios
AU - Hunt, Jennifer L.
AU - Rinaldo, Alessandra
AU - Strojan, Primož
AU - Haigentz, Missak
AU - Mendenhall, William M.
AU - Takes, Robert P.
AU - Vander Poorten, Vincent
AU - Ferlito, Alfio
N1 - Publisher Copyright:
© 2014, Springer-Verlag Berlin Heidelberg.
PY - 2015/4
Y1 - 2015/4
N2 - Clinicopathological features, prognosis and therapeutic strategies for mucoepidermoid carcinoma originating in salivary and salivary-type glands of the head and neck are reviewed. We emphasise histopathological aspects, appraise the value of histochemistry, electron microscopy, immunohistochemistry and cytophotometry, and discuss histogenesis and characteristic gene translocations. We additionally consider possible diagnostic difficulties, problems related to histological grading and accuracy of existing literature, and areas of controversy or uncertainty which may benefit from further investigations.
AB - Clinicopathological features, prognosis and therapeutic strategies for mucoepidermoid carcinoma originating in salivary and salivary-type glands of the head and neck are reviewed. We emphasise histopathological aspects, appraise the value of histochemistry, electron microscopy, immunohistochemistry and cytophotometry, and discuss histogenesis and characteristic gene translocations. We additionally consider possible diagnostic difficulties, problems related to histological grading and accuracy of existing literature, and areas of controversy or uncertainty which may benefit from further investigations.
KW - Head and neck
KW - Mucoepidermoid carcinoma
KW - Pathology
KW - Prognosis
KW - Salivary glands
KW - Therapy
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U2 - 10.1007/s00405-014-3053-z
DO - 10.1007/s00405-014-3053-z
M3 - Review article
C2 - 24771140
AN - SCOPUS:84939880495
VL - 272
SP - 799
EP - 819
JO - European Archives of Oto-Rhino-Laryngology
JF - European Archives of Oto-Rhino-Laryngology
SN - 0937-4477
IS - 4
ER -