Safety profile and cellular uptake of biotemplated nanocapsules with nanometre-thin walls

Qunfang Zhou, Sergey A. Dergunov, Yi Zhang, Xi Li, Qingxin Mu, Qiu Zhang, Guibin Jiang, Eugene Pinkhassik, Bing Yan

Research output: Contribution to journalArticle

Abstract

Polymeric nanocapsules with nanometre-thin walls offer a promising platform for controlled cellular delivery of therapeutic or diagnostic agents. Therefore, their biocompatibility is crucial for future applications in the human body. However, there is little knowledge about their interaction with biological systems. In this study, polymeric nanocapsules containing different amounts of lipids and representing different scenarios for handling and storing nanocapsules are investigated. We find that all nanocapsules in our study can enter human cells and the presence of an outer lipid shell facilitates the process. These nanocapsules do not inhibit cell proliferation at concentrations up to 200 μg mL−1 of nanocapsules. No cellular ROS, apoptosis or cell cycle perturbation is detected at this dose. These comprehensive examinations demonstrate that polymeric nanocapsules are promising nano-carriers for cellular delivery.

Original languageEnglish (US)
Pages (from-to)2576-2582
Number of pages7
JournalNanoscale
Volume3
Issue number6
DOIs
StatePublished - Jun 8 2011
Externally publishedYes

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Nanocapsules
Materials testing
Flow cytometry
Reactive Oxygen Species
Apoptosis
Transmission electron microscopy
Lipids
Cells
Cell proliferation
Biological systems
Drug Delivery Systems
Biocompatibility

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Safety profile and cellular uptake of biotemplated nanocapsules with nanometre-thin walls. / Zhou, Qunfang; Dergunov, Sergey A.; Zhang, Yi; Li, Xi; Mu, Qingxin; Zhang, Qiu; Jiang, Guibin; Pinkhassik, Eugene; Yan, Bing.

In: Nanoscale, Vol. 3, No. 6, 08.06.2011, p. 2576-2582.

Research output: Contribution to journalArticle

Zhou, Q, Dergunov, SA, Zhang, Y, Li, X, Mu, Q, Zhang, Q, Jiang, G, Pinkhassik, E & Yan, B 2011, 'Safety profile and cellular uptake of biotemplated nanocapsules with nanometre-thin walls', Nanoscale, vol. 3, no. 6, pp. 2576-2582. https://doi.org/10.1039/c1nr10311c
Zhou, Qunfang ; Dergunov, Sergey A. ; Zhang, Yi ; Li, Xi ; Mu, Qingxin ; Zhang, Qiu ; Jiang, Guibin ; Pinkhassik, Eugene ; Yan, Bing. / Safety profile and cellular uptake of biotemplated nanocapsules with nanometre-thin walls. In: Nanoscale. 2011 ; Vol. 3, No. 6. pp. 2576-2582.
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