Safety of using hepatitis B virus core antibody or surface antigen-positive donors in kidney or pancreas tranplantation

Enver Akalin, Scott Ames, Vinita Sehgal, Barbara Murphy, Jonathan S. Bromberg

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Hepatitis B virus core antibody (HBcAb) or surface antigen (HBsAg)-positive organ donors have the potential to transmit infection to transplant recipients. We investigated the safety of using HBcAb(+) or HBsAg(+) donors in kidney or pancreas transplant recipients with 1 yr lamivudine prophylaxis. While HBsAb(-) recipients of HBcAb(+) donors received prophylaxis, HBsAb(+) recipients did not. HBsAg(+) organs were only used in patients who were both HBcAb and HBsAb(+). Forty-six patients received HBcAb(+) and four received HBsAg(+) organs (47 kidney, two pancreas, and one kidney/pancreas). All but one recipient were HBsAg(-), 25 were HBsAb(+), and 19 HBcAb(+). During a median 36 months of follow-up (range 6-66 months), with 43 of a total 50 patients having at least 1 yr follow-up and were off lamivudine, and none of the patients developed hepatitis B viremia or seroconversion to HBsAg or HBsAb(+). These results suggest that HBcAb(+) or HBsAg(+) organs can be used safely in selected recipients with lamivudine prophylaxis without requiring hepatitis B immunglobulin.

Original languageEnglish (US)
Pages (from-to)364-366
Number of pages3
JournalClinical Transplantation
Volume19
Issue number3
DOIs
StatePublished - Jun 1 2005
Externally publishedYes

Keywords

  • Hepatitis B core antibody
  • Kidney transplantation
  • Lamivudine

ASJC Scopus subject areas

  • Transplantation

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