Safety and efficacy of intravenous combination sedatives in the ED

Siu Fai Li, Amy Kumar, Susan Thomas, Yelena Sorokina, Vanessa Calderon, Elizabeth Dubey, Lani Lee, Ludmilla Gustave

Research output: Contribution to journalArticle

3 Scopus citations


Objective: The objective of the study is to determine the safety of intravenously administered combination sedatives in the emergency department (ED). Methods: This was a retrospective study of alcohol-intoxicated patients in the ED. We examined the incidence of adverse events in agitated patients who received combination sedatives intravenously and compared the efficacy of combination sedatives and single-agent sedatives. Results: Of 1300 patient visits, there was a single adverse event, a dystonic reaction, in the combination sedative group, for an adverse event rate of less than 1%. Patients who received combination sedatives were less likely to require a second dose of sedative medication than patients who received a single-agent sedative (21% vs 44%). Conclusions: Combination sedatives appear to be safe when administered intravenously in the ED. Combination sedatives may be more effective than single-agent sedatives in agitated alcohol-intoxicated patients.

Original languageEnglish (US)
Pages (from-to)1402-1404
Number of pages3
JournalAmerican Journal of Emergency Medicine
Issue number9
Publication statusPublished - Sep 1 2013


ASJC Scopus subject areas

  • Emergency Medicine

Cite this

Li, S. F., Kumar, A., Thomas, S., Sorokina, Y., Calderon, V., Dubey, E., ... Gustave, L. (2013). Safety and efficacy of intravenous combination sedatives in the ED. American Journal of Emergency Medicine, 31(9), 1402-1404.