Safety and efficacy of intravenous combination sedatives in the ED

Siu Fai Li, Amy Kumar, Susan Thomas, Yelena Sorokina, Vanessa Calderon, Elizabeth Dubey, Lani Lee, Ludmilla Gustave

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Objective: The objective of the study is to determine the safety of intravenously administered combination sedatives in the emergency department (ED). Methods: This was a retrospective study of alcohol-intoxicated patients in the ED. We examined the incidence of adverse events in agitated patients who received combination sedatives intravenously and compared the efficacy of combination sedatives and single-agent sedatives. Results: Of 1300 patient visits, there was a single adverse event, a dystonic reaction, in the combination sedative group, for an adverse event rate of less than 1%. Patients who received combination sedatives were less likely to require a second dose of sedative medication than patients who received a single-agent sedative (21% vs 44%). Conclusions: Combination sedatives appear to be safe when administered intravenously in the ED. Combination sedatives may be more effective than single-agent sedatives in agitated alcohol-intoxicated patients.

Original languageEnglish (US)
Pages (from-to)1402-1404
Number of pages3
JournalAmerican Journal of Emergency Medicine
Issue number9
StatePublished - Sep 1 2013

ASJC Scopus subject areas

  • Emergency Medicine

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