Rumination in major depressive disorder is associated with impaired neural activation during conflict monitoring

Brandon L. Alderman, Ryan L. Olson, Marsha E. Bates, Edward A. Selby, Jennifer F. Buckman, Christopher J. Brush, Emily A. Panza, Amy Kranzler, David Eddie, Tracey J. Shors

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Individuals with major depressive disorder (MDD) often ruminate about past experiences, especially those with negative content. These repetitive thoughts may interfere with cognitive processes related to attention and conflict monitoring. However, the temporal nature of these processes as reflected in event-related potentials (ERPs) has not been well-described. We examined behavioral and ERP indices of conflict monitoring during a modified flanker task and the allocation of attention during an attentional blink (AB) task in 33 individuals with MDD and 36 healthy controls, and whether their behavioral performance and ERPs varied with level of rumination. N2 amplitude elicited by the flanker task was significantly reduced in participants with MDD compared to healthy controls. Level of self-reported rumination was also correlated with N2 amplitude. In contrast, P3 amplitude during the AB task was not significantly different between groups, nor was it correlated with rumination. No significant differences were found in behavioral task performance measures between groups or by rumination levels. These findings suggest that rumination in MDD is associated with select deficits in cognitive control, particularly related to conflict monitoring.

Original languageEnglish (US)
Article number269
JournalFrontiers in Human Neuroscience
Volume9
Issue numberMAY
DOIs
StatePublished - May 12 2015
Externally publishedYes

Fingerprint

Major Depressive Disorder
Attentional Blink
Evoked Potentials
Task Performance and Analysis
Conflict (Psychology)

Keywords

  • Anterior cingulate cortex
  • Cognitive control
  • Depression
  • Dorsolateral prefrontal cortex
  • N2
  • P3

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

Alderman, B. L., Olson, R. L., Bates, M. E., Selby, E. A., Buckman, J. F., Brush, C. J., ... Shors, T. J. (2015). Rumination in major depressive disorder is associated with impaired neural activation during conflict monitoring. Frontiers in Human Neuroscience, 9(MAY), [269]. https://doi.org/10.3389/fnhum.2015.00269

Rumination in major depressive disorder is associated with impaired neural activation during conflict monitoring. / Alderman, Brandon L.; Olson, Ryan L.; Bates, Marsha E.; Selby, Edward A.; Buckman, Jennifer F.; Brush, Christopher J.; Panza, Emily A.; Kranzler, Amy; Eddie, David; Shors, Tracey J.

In: Frontiers in Human Neuroscience, Vol. 9, No. MAY, 269, 12.05.2015.

Research output: Contribution to journalArticle

Alderman, BL, Olson, RL, Bates, ME, Selby, EA, Buckman, JF, Brush, CJ, Panza, EA, Kranzler, A, Eddie, D & Shors, TJ 2015, 'Rumination in major depressive disorder is associated with impaired neural activation during conflict monitoring', Frontiers in Human Neuroscience, vol. 9, no. MAY, 269. https://doi.org/10.3389/fnhum.2015.00269
Alderman, Brandon L. ; Olson, Ryan L. ; Bates, Marsha E. ; Selby, Edward A. ; Buckman, Jennifer F. ; Brush, Christopher J. ; Panza, Emily A. ; Kranzler, Amy ; Eddie, David ; Shors, Tracey J. / Rumination in major depressive disorder is associated with impaired neural activation during conflict monitoring. In: Frontiers in Human Neuroscience. 2015 ; Vol. 9, No. MAY.
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