Roles of the cytoskeleton and motor proteins in endocytic sorting

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

After internalization, endocytic material is actively transported through the cytoplasm, predominantly by microtubule motor proteins. Microtubule-based endocytic transport facilitates sorting of endocytic contents, vesicle fusion and fission, delivery to lysosomes, cytosolic dispersal, as well as nuclear uptake and cytosolic egress of pathogens. Endosomes, like most organelles, move bidirectionally through the cytosol and regulate their cellular location by controlling the activity of motor proteins, and potentially by controlling microtubule and actin polymerization. Control of motor protein activity is manifest by increased microtubule "run lengths", and the binding of motor proteins to organelles can be regulated by motor protein receptors. A mechanistic understanding of how organelles control motor protein activity to allow for endocytic sorting presents an exciting avenue for future research.

Original languageEnglish (US)
Pages (from-to)1385-1403
Number of pages19
JournalAdvanced Drug Delivery Reviews
Volume55
Issue number11
DOIs
StatePublished - Nov 14 2003

Keywords

  • Actin
  • Dynein
  • Endocytosis
  • Kinesin
  • Lipids
  • Microtubules
  • Myosin
  • Rabs
  • Virus

ASJC Scopus subject areas

  • Pharmaceutical Science

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