TY - JOUR
T1 - Roles of O-Fucose Glycans in Notch Signaling Revealed by Mutant Mice
AU - Lu, Linchao
AU - Stanley, Pamela
N1 - Funding Information:
This work was supported by NCI grant RO1 95022 to PS.
PY - 2006
Y1 - 2006
N2 - Notch receptor signaling is important for many developmental processes in the metazoa. Insights into how Notch receptor signaling is regulated have been obtained from the characterization of mutants of model organisms in which Notch signaling is perturbed. Here we describe the effects of mutations that alter the glycosylation of Notch receptors and Notch ligands in the mouse. The extracellular domain of Notch receptors and Notch ligands carries N-glycans and O-glycans, including O-fucose and O-glucose glycans. Mutations in several genes that inhibit the synthesis of O-fucose glycans, and one that also affects the maturation of N-glycans, cause Notch signaling defects and disrupt development.
AB - Notch receptor signaling is important for many developmental processes in the metazoa. Insights into how Notch receptor signaling is regulated have been obtained from the characterization of mutants of model organisms in which Notch signaling is perturbed. Here we describe the effects of mutations that alter the glycosylation of Notch receptors and Notch ligands in the mouse. The extracellular domain of Notch receptors and Notch ligands carries N-glycans and O-glycans, including O-fucose and O-glucose glycans. Mutations in several genes that inhibit the synthesis of O-fucose glycans, and one that also affects the maturation of N-glycans, cause Notch signaling defects and disrupt development.
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U2 - 10.1016/S0076-6879(06)17010-X
DO - 10.1016/S0076-6879(06)17010-X
M3 - Review article
C2 - 17132502
AN - SCOPUS:33751218061
VL - 417
SP - 127
EP - 136
JO - Methods in Enzymology
JF - Methods in Enzymology
SN - 0076-6879
ER -