Roles of glycosylation in notch signaling

Pamela Stanley, Tetsuya Okajima

Research output: Book/ReportBook

84 Citations (Scopus)

Abstract

Notch and the DSL Notch ligands Delta and Serrate/Jagged are glycoproteins with a single transmembrane domain. The extracellular domain (ECD) of both Notch receptors and Notch ligands contains numerous epidermal growth factor (EGF)-like repeats which are post-translationally modified by a variety of glycans. Inactivation of a subset of genes that encode glycosyltransferases which initiate and elongate these glycans inhibits Notch signaling. In the formation of developmental boundaries in Drosophila and mammals, in mouse T-cell and marginal zone B-cell development, and in co-culture Notch signaling assays, the regulation of Notch signaling by glycans is to date a cell-autonomous effect of the Notch-expressing cell. The regulation of Notch signaling by glycans represents a new paradigm of signal transduction. O-fucose glycans modulate the strength of Notch binding to DSL Notch ligands, while O-glucose glycans facilitate juxta-membrane cleavage of Notch, generating the substrate for intramembrane cleavage and Notch activation. Identifying precisely how the addition of particular sugars at specific locations on Notch modifies Notch signaling is a challenge for the future.

Original languageEnglish (US)
PublisherUnknown Publisher
Number of pages34
Volume92
EditionC
DOIs
StatePublished - 2010

Publication series

NameCurrent Topics in Developmental Biology
No.C
Volume92
ISSN (Print)00702153

Fingerprint

Glycosylation
Polysaccharides
Ligands
Notch Receptors
Glycosyltransferases
Fucose
Coculture Techniques
Epidermal Growth Factor
Drosophila
Mammals
Signal Transduction
Glycoproteins
B-Lymphocytes
T-Lymphocytes
Glucose
Membranes
Genes

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology

Cite this

Stanley, P., & Okajima, T. (2010). Roles of glycosylation in notch signaling. (C ed.) (Current Topics in Developmental Biology; Vol. 92, No. C). Unknown Publisher. https://doi.org/10.1016/S0070-2153(10)92004-8

Roles of glycosylation in notch signaling. / Stanley, Pamela; Okajima, Tetsuya.

C ed. Unknown Publisher, 2010. 34 p. (Current Topics in Developmental Biology; Vol. 92, No. C).

Research output: Book/ReportBook

Stanley, P & Okajima, T 2010, Roles of glycosylation in notch signaling. Current Topics in Developmental Biology, no. C, vol. 92, vol. 92, C edn, Unknown Publisher. https://doi.org/10.1016/S0070-2153(10)92004-8
Stanley P, Okajima T. Roles of glycosylation in notch signaling. C ed. Unknown Publisher, 2010. 34 p. (Current Topics in Developmental Biology; C). https://doi.org/10.1016/S0070-2153(10)92004-8
Stanley, Pamela ; Okajima, Tetsuya. / Roles of glycosylation in notch signaling. C ed. Unknown Publisher, 2010. 34 p. (Current Topics in Developmental Biology; C).
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