Roles for central leptin receptors in the control of meal size

Gary J. Schwartz, Anthony V. Azzara, Martica K. Heaner

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

The adiposity hormone leptin has been implicated in the regulation of behavioral and metabolic controls of body weight. Leptin receptors are found in multiple peripheral and central tissues, particularly within hypothalamic and brainstem neuronal populations. Central leptinergic signaling acts as an indirect control to modulate the feeding inhibitory potency of the direct controls of meal size. Mouse models of neuronal leptin loss and gain of function have helped to identify and characterize how central leptin contributes to the central control of food intake.

Original languageEnglish (US)
Pages (from-to)466-469
Number of pages4
JournalAppetite
Volume71
DOIs
Publication statusPublished - Dec 1 2013

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Keywords

  • Brainstem
  • Food intake
  • Hypothalamus
  • LepRb
  • Leptin
  • Meal size

ASJC Scopus subject areas

  • Psychology(all)
  • Nutrition and Dietetics

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