Role of Vitamin D Receptor Activation in Racial Disparities in Kidney Disease Outcomes

Utibe Essien, Narender Goel, Michal L. Melamed

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

African Americans have lower 25-hydroxyvitamin D (25(OH)D) levels compared with whites. African Americans also have a higher risk of developing albuminuria and end-stage renal disease but a lower risk of death once they commence hemodialysis compared with whites. Vitamin D levels have been associated with multiple outcomes including albuminuria, progression to end-stage renal disease, and all-cause and cardiovascular mortality. In this review, we examine the evidence linking 25(OH)D to outcomes and the possibility that differential 25(OH)D may explain certain racial differences in outcomes.

Original languageEnglish (US)
Pages (from-to)416-424
Number of pages9
JournalSeminars in Nephrology
Volume33
Issue number5
DOIs
StatePublished - Sep 1 2013

Keywords

  • Albuminuria
  • Chronic kidney disease
  • Mortality
  • Racial differences
  • Vitamin D

ASJC Scopus subject areas

  • Nephrology

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