TY - JOUR
T1 - Role of vasoactive mediators in the pathogenesis of Chagas' disease.
AU - Mukherjee, Shankar
AU - Huang, Huan
AU - Weiss, Louis M.
AU - Costa, Sylvia
AU - Scharfstein, Julio
AU - Tanowitz, Herbert B.
PY - 2003/5/1
Y1 - 2003/5/1
N2 - This review focuses on the vascular pathogenesis of Chagas' disease, the cardiomyopathy caused by infection with the parasitic protozoa Trypanosoma cruzi. Recent studies strongly suggests that T. cruzi infection is linked to functional changes in the activity of two potent vasoactive peptidergic mediators, endothelin-1, a vasoconstrictor, and kinins, a group of vasodilator and pro-inflammatory peptides related to bradykinin. Understanding the molecular mechanisms underlying disturbances of vascular homoeostasis? induced by T. cruzi may provide opportunities for therapeutic intervention and amelioration of heart pathology.
AB - This review focuses on the vascular pathogenesis of Chagas' disease, the cardiomyopathy caused by infection with the parasitic protozoa Trypanosoma cruzi. Recent studies strongly suggests that T. cruzi infection is linked to functional changes in the activity of two potent vasoactive peptidergic mediators, endothelin-1, a vasoconstrictor, and kinins, a group of vasodilator and pro-inflammatory peptides related to bradykinin. Understanding the molecular mechanisms underlying disturbances of vascular homoeostasis? induced by T. cruzi may provide opportunities for therapeutic intervention and amelioration of heart pathology.
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UR - http://www.scopus.com/inward/citedby.url?scp=1542673236&partnerID=8YFLogxK
U2 - 10.2741/1103
DO - 10.2741/1103
M3 - Review article
C2 - 12700081
AN - SCOPUS:1542673236
SN - 1093-9946
VL - 8
SP - e410-419
JO - Frontiers in Bioscience - Landmark
JF - Frontiers in Bioscience - Landmark
ER -
