Role of vasoactive mediators in the pathogenesis of Chagas' disease.

Shankar Mukherjee, Huan Huang, Louis M. Weiss, Sylvia Costa, Julio Scharfstein, Herbert B. Tanowitz

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


This review focuses on the vascular pathogenesis of Chagas' disease, the cardiomyopathy caused by infection with the parasitic protozoa Trypanosoma cruzi. Recent studies strongly suggests that T. cruzi infection is linked to functional changes in the activity of two potent vasoactive peptidergic mediators, endothelin-1, a vasoconstrictor, and kinins, a group of vasodilator and pro-inflammatory peptides related to bradykinin. Understanding the molecular mechanisms underlying disturbances of vascular homoeostasis? induced by T. cruzi may provide opportunities for therapeutic intervention and amelioration of heart pathology.

Original languageEnglish (US)
Pages (from-to)e410-419
JournalFrontiers in bioscience : a journal and virtual library
StatePublished - May 1 2003

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)


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